HCSGD entry for ORAI1

1. General information

Official gene symbolORAI1
Entrez ID84876
Gene full nameORAI calcium release-activated calcium modulator 1
Other gene symbolsCRACM1 ORAT1 TMEM142A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002115Store-operated calcium entryIEAbiological_process
GO:0002376Immune system processIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0007596Blood coagulationTASbiological_process
GO:0015279Store-operated calcium channel activityIDAmolecular_function
GO:0043234Protein complexIEAcellular_component
GO:0051924Regulation of calcium ion transportIMPbiological_process
GO:0051928Positive regulation of calcium ion transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00278467380.95010965010.14177659571.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6049664669
GSE13712_SHEARUp0.0595467641
GSE13712_STATICUp0.2535383836
GSE19018Down-0.0627332858
GSE19899_A1Up0.5249180835
GSE19899_A2Up2.1937443455
PubMed_21979375_A1Up2.7317320729
PubMed_21979375_A2Up2.0815121136
GSE35957Down-0.6151142647
GSE36640Up0.0682084656
GSE54402Up0.7081471596
GSE9593Down-0.2390431233
GSE43922Up0.5161538359
GSE24585Up0.6264501356
GSE37065Down-0.0757610746
GSE28863_A1Down-0.0326388569
GSE28863_A2Down-0.1057400537
GSE28863_A3Up0.2992754243
GSE28863_A4Up0.1487321395
GSE48662Down-0.1884023631

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26257076The importance of store-operated Ca(2+) entry (SOCE) and the role of its key molecular regulators, STIM1 and ORAI1, in the development of cancer are emerging
26257076In addition, STIM1 and ORAI1 inhibited NF-kappaB signaling and remodeled the tumor microenvironment by reducing the formation of M2 phenotype macrophages, possibly creating an unfavorable tumor microenvironment and inhibiting cancer development
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