HCSGD entry for HAVCR2
1. General information
| Official gene symbol | HAVCR2 |
|---|---|
| Entrez ID | 84868 |
| Gene full name | hepatitis A virus cellular receptor 2 |
| Other gene symbols | HAVcr-2 KIM-3 TIM3 TIMD-3 TIMD3 Tim-3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0832663691 | 0.9832506440 | 0.6081171199 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0137727689 |
| GSE13712_SHEAR | Up | 0.0786211974 |
| GSE13712_STATIC | Down | -0.0116387759 |
| GSE19018 | Up | 0.0455447153 |
| GSE19899_A1 | Up | 0.1539778637 |
| GSE19899_A2 | Up | 0.3503500769 |
| PubMed_21979375_A1 | Up | 1.2473204087 |
| PubMed_21979375_A2 | Up | 0.3184637248 |
| GSE35957 | Up | 0.1191063951 |
| GSE36640 | Up | 0.1416894674 |
| GSE54402 | Up | 0.3280150993 |
| GSE9593 | Up | 0.0980671185 |
| GSE43922 | Up | 0.4102130417 |
| GSE24585 | Up | 0.0450433200 |
| GSE37065 | Up | 0.3689900242 |
| GSE28863_A1 | Down | -0.1697645780 |
| GSE28863_A2 | Up | 0.0186329440 |
| GSE28863_A3 | Up | 0.2154594593 |
| GSE28863_A4 | Up | 0.1463015584 |
| GSE48662 | Down | -0.0379033476 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23029209 | Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children |
| 23029209 | Targeting Tim-3 may serve as a novel therapeutic approach to improve immune control of virus replication and mitigate age related T cell exhaustion |
| 22505239 | Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma |
| 22505239 | UNLABELLED: The interaction between T cell immunoglobulin mucin-domain-containing molecule (Tim-3) expressed on T helper 1 (Th1) cells, and its ligand, galectin-9, negatively regulates Th1-mediated immune responses |
| 22505239 | Functional studies demonstrated that blockade of the Tim-3/galectin-9 signaling pathway importantly increased the functionality of tumor-infiltrating Tim-3(+) T cells as shown by increased T-cell proliferation and effector cytokine production |
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