HCSGD entry for RAE1
1. General information
| Official gene symbol | RAE1 |
|---|---|
| Entrez ID | 8480 |
| Gene full name | RAE1 RNA export 1 homolog (S. pombe) |
| Other gene symbols | MIG14 MRNP41 Mnrp41 dJ481F12.3 dJ800J21.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005635 | Nuclear envelope | TAS | cellular_component |
| GO:0005640 | Nuclear outer membrane | TAS | cellular_component |
| GO:0005643 | Nuclear pore | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006406 | MRNA export from nucleus | TAS | biological_process |
| GO:0007077 | Mitotic nuclear envelope disassembly | TAS | biological_process |
| GO:0008017 | Microtubule binding | ISS | molecular_function |
| GO:0008645 | Hexose transport | TAS | biological_process |
| GO:0010827 | Regulation of glucose transport | TAS | biological_process |
| GO:0015758 | Glucose transport | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0071407 | Cellular response to organic cyclic compound | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3017018996 | 0.6989686486 | 0.9996978348 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3260444866 |
| GSE13712_SHEAR | Down | -0.0285625081 |
| GSE13712_STATIC | Up | 0.1468255913 |
| GSE19018 | Down | -0.1316119470 |
| GSE19899_A1 | Down | -0.1318652938 |
| GSE19899_A2 | Up | 0.1303989031 |
| PubMed_21979375_A1 | Up | 0.5444233904 |
| PubMed_21979375_A2 | Up | 0.1095737295 |
| GSE35957 | Down | -0.3590455185 |
| GSE36640 | Down | -0.2559572868 |
| GSE54402 | Up | 0.2030043790 |
| GSE9593 | Down | -0.0789078984 |
| GSE43922 | Up | 0.0079868753 |
| GSE24585 | Down | -0.0415705816 |
| GSE37065 | Down | -0.0825918380 |
| GSE28863_A1 | Up | 0.3932680294 |
| GSE28863_A2 | Up | 0.5091279147 |
| GSE28863_A3 | Up | 0.1407967835 |
| GSE28863_A4 | Down | -0.2005790009 |
| GSE48662 | Down | -0.0889430625 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025213 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029494 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044107 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045362 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046487 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27853638 | Melphalan treatment was able to enhance the surface expression of the stress-induced NKG2D ligands RAE-1 and MULT-1, and of the DNAM-1 ligand PVR (CD155) on MM cells, leading to better tumor cell recognition and killing by NK cells, as highlighted by NK cell increased degranulation triggered by melphalan-treated tumor cells |
| 27853638 | Furthermore, we showed that low doses of melphalan fail to induce tumor cell apoptosis, but promote the in vivo establishment of a senescent tumor cell population, harboring high levels of the stress-induced ligands RAE-1 and PVR |
| 16600919 | In addition to conserved Bub and Mad family members, which are known to function in the spindle checkpoint pathway in organisms ranging from yeast to mammals, two mRNA transport genes, Rae1 and Nup9, are also involved in the spindle checkpoint function in mammals |
| 16600919 | Interestingly, a recent study has shed light on a new function of the spindle checkpoint components Bub3 and Rae1 in the regulation of aging |
| 16600919 | Mice with haploinsufficiency of Bub3 and Rae1 have a short life span that is associated with the early onset of aging-related features |
| 16600919 | The progeroid phenotypes caused by deficiency of Bub3 and Rae1 are tightly linked to precocious activation of cellular senescence, but not apoptotic, programs |
| 16476774 | In this study, we show that several aging-associated phenotypes appear early in mice that are double haploinsufficient for the mitotic checkpoint genes Bub3 and Rae1 but not in mice that are single haploinsufficient for these genes |
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