HCSGD entry for IRS4
1. General information
| Official gene symbol | IRS4 |
|---|---|
| Entrez ID | 8471 |
| Gene full name | insulin receptor substrate 4 |
| Other gene symbols | IRS-4 PY160 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005158 | Insulin receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9466508377 | 0.2689373580 | 0.9999902473 | 0.9925447841 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0598653859 |
| GSE13712_SHEAR | Up | 0.0919710131 |
| GSE13712_STATIC | Down | -0.0053660562 |
| GSE19018 | Up | 0.0156397270 |
| GSE19899_A1 | Down | -0.0472223830 |
| GSE19899_A2 | Down | -0.0493433638 |
| PubMed_21979375_A1 | Up | 0.1163548840 |
| PubMed_21979375_A2 | Down | -0.0741989006 |
| GSE35957 | Up | 0.0272453312 |
| GSE36640 | Up | 0.0155165230 |
| GSE54402 | Up | 0.1356403857 |
| GSE9593 | Down | -0.0207732844 |
| GSE43922 | Up | 0.0125365483 |
| GSE24585 | Down | -0.6974360762 |
| GSE37065 | Down | -0.0069510972 |
| GSE28863_A1 | Down | -0.1791730282 |
| GSE28863_A2 | Down | -0.0804223705 |
| GSE28863_A3 | Down | -0.1176955008 |
| GSE28863_A4 | Down | -0.1213605113 |
| GSE48662 | Up | 0.0245083847 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-744-5p | MIMAT0004945 | MIRT037488 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-330-5p | MIMAT0004693 | MIRT038245 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039541 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040218 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040876 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041502 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042143 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043291 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045789 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046069 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046599 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050656 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051115 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051562 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052242 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
