HCSGD entry for SORBS2


1. General information

Official gene symbolSORBS2
Entrez ID8470
Gene full namesorbin and SH3 domain containing 2
Other gene symbolsARGBP2 PRO0618
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005200Structural constituent of cytoskeletonTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusNAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007015Actin filament organizationIEAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0008093Cytoskeletal adaptor activityTASmolecular_function
GO:0008150Biological_processNDbiological_process
GO:0008307Structural constituent of muscleTASmolecular_function
GO:0015629Actin cytoskeletonTAScellular_component
GO:0016477Cell migrationIEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030018Z discNAScellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12796499750.85523652980.72730872381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0882852781
GSE13712_SHEARUp0.1377401854
GSE13712_STATICUp0.0286846655
GSE19018Up0.1075223938
GSE19899_A1Up0.1205905653
GSE19899_A2Up0.2839212265
PubMed_21979375_A1Up0.0369886319
PubMed_21979375_A2Up0.2760884794
GSE35957Down-0.3275916384
GSE36640Up0.0452157661
GSE54402Up0.3025786335
GSE9593Down-0.2359337406
GSE43922Up0.1352354652
GSE24585Down-0.0164802371
GSE37065Down-0.0175055261
GSE28863_A1Up0.3212312710
GSE28863_A2Down-0.3778572181
GSE28863_A3Up0.3837812796
GSE28863_A4Down-0.1358947998
GSE48662Up0.3569054373

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016899MicroarrayFunctional MTI (Weak)18185580
hsa-miR-1226-3pMIMAT0005577MIRT036452CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24165198SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes
24165198Of interest is the novel finding that SORBS2 and TLR3 can induce senescence in primary human fibroblasts and keratinocytes but not in HPV-immortalized cell lines
24165198CONCLUSIONS: The relevance of the genes SORBS2 and TLR3 in the process of cellular senescence warrants further investigation
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