HCSGD entry for SORBS2
1. General information
Official gene symbol | SORBS2 |
---|---|
Entrez ID | 8470 |
Gene full name | sorbin and SH3 domain containing 2 |
Other gene symbols | ARGBP2 PRO0618 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005634 | Nucleus | NAS | cellular_component |
GO:0005886 | Plasma membrane | IEA | cellular_component |
GO:0007015 | Actin filament organization | IEA | biological_process |
GO:0007155 | Cell adhesion | IEA | biological_process |
GO:0008093 | Cytoskeletal adaptor activity | TAS | molecular_function |
GO:0008150 | Biological_process | ND | biological_process |
GO:0008307 | Structural constituent of muscle | TAS | molecular_function |
GO:0015629 | Actin cytoskeleton | TAS | cellular_component |
GO:0016477 | Cell migration | IEA | biological_process |
GO:0019904 | Protein domain specific binding | IEA | molecular_function |
GO:0030018 | Z disc | NAS | cellular_component |
GO:0046872 | Metal ion binding | IEA | molecular_function |
GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.1279649975 | 0.8552365298 | 0.7273087238 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.0882852781 |
GSE13712_SHEAR | Up | 0.1377401854 |
GSE13712_STATIC | Up | 0.0286846655 |
GSE19018 | Up | 0.1075223938 |
GSE19899_A1 | Up | 0.1205905653 |
GSE19899_A2 | Up | 0.2839212265 |
PubMed_21979375_A1 | Up | 0.0369886319 |
PubMed_21979375_A2 | Up | 0.2760884794 |
GSE35957 | Down | -0.3275916384 |
GSE36640 | Up | 0.0452157661 |
GSE54402 | Up | 0.3025786335 |
GSE9593 | Down | -0.2359337406 |
GSE43922 | Up | 0.1352354652 |
GSE24585 | Down | -0.0164802371 |
GSE37065 | Down | -0.0175055261 |
GSE28863_A1 | Up | 0.3212312710 |
GSE28863_A2 | Down | -0.3778572181 |
GSE28863_A3 | Up | 0.3837812796 |
GSE28863_A4 | Down | -0.1358947998 |
GSE48662 | Up | 0.3569054373 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-335-5p | MIMAT0000765 | MIRT016899 | Microarray | Functional MTI (Weak) | 18185580 |
hsa-miR-1226-3p | MIMAT0005577 | MIRT036452 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
24165198 | SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes |
24165198 | Of interest is the novel finding that SORBS2 and TLR3 can induce senescence in primary human fibroblasts and keratinocytes but not in HPV-immortalized cell lines |
24165198 | CONCLUSIONS: The relevance of the genes SORBS2 and TLR3 in the process of cellular senescence warrants further investigation |
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