HCSGD entry for LOXL3
1. General information
| Official gene symbol | LOXL3 |
|---|---|
| Entrez ID | 84695 |
| Gene full name | lysyl oxidase-like 3 |
| Other gene symbols | LOXL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001837 | Epithelial to mesenchymal transition | IDA | biological_process |
| GO:0004720 | Protein-lysine 6-oxidase activity | NAS | molecular_function |
| GO:0005044 | Scavenger receptor activity | IEA | molecular_function |
| GO:0005507 | Copper ion binding | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IDA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016641 | Oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | IEA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3217942479 | 0.0007095019 | 0.9999902473 | 0.0502010753 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.3585938283 |
| GSE13712_SHEAR | Down | -0.1531746500 |
| GSE13712_STATIC | Down | -0.0037817816 |
| GSE19018 | Up | 1.3938548186 |
| GSE19899_A1 | Down | -1.3807281050 |
| GSE19899_A2 | Down | -3.4589321258 |
| PubMed_21979375_A1 | Down | -2.4194330814 |
| PubMed_21979375_A2 | Down | -1.4812227434 |
| GSE35957 | Down | -1.1431797104 |
| GSE36640 | Down | -0.3293953361 |
| GSE54402 | Down | -1.5720733173 |
| GSE9593 | Up | 1.1456251699 |
| GSE43922 | Down | -1.2366331814 |
| GSE24585 | Up | 0.1626106793 |
| GSE37065 | Down | -0.1106742369 |
| GSE28863_A1 | Down | -0.1505517593 |
| GSE28863_A2 | Up | 1.2100421212 |
| GSE28863_A3 | Down | -1.0402431503 |
| GSE28863_A4 | Up | 0.1602242509 |
| GSE48662 | Down | -0.2636648433 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26011922 | LOX and LOXL1, 2 and 4 were localized to both amniotic and chorionic cells, whereas LOXL3 was limited to chorion |
| 11642359 | However, specific novel functions, such as a potential role in cell adhesion and cell growth control, will be determined by other, conserved domains such as the cytokine receptor-like domain that is shared by all LOXs and by multiple scavenger receptor cysteine-rich (SRCR) domains present in LOXL2 and LOXL3 |
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