HCSGD entry for GLIS2

1. General information

Official gene symbolGLIS2
Entrez ID84662
Gene full nameGLIS family zinc finger 2
Other gene symbolsNKL NPHP7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0016607Nuclear speckISScellular_component
GO:0030154Cell differentiationIEAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityISSbiological_process
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0045879Negative regulation of smoothened signaling pathwayISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79735703050.04494971700.99999024730.3988946392

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5287156620
GSE13712_SHEARDown-0.6107277052
GSE13712_STATICDown-0.3199204036
GSE19018Down-0.2837615706
GSE19899_A1Down-0.3524198657
GSE19899_A2Down-0.3043279341
PubMed_21979375_A1Down-0.7633400189
PubMed_21979375_A2Down-0.3124993258
GSE35957Down-0.1188225827
GSE36640Up0.6249607743
GSE54402Down-0.2259312577
GSE9593Up0.3055185901
GSE43922Down-0.0771415284
GSE24585Down-0.0178147143
GSE37065Down-0.1845048802
GSE28863_A1Up0.1072014022
GSE28863_A2Down-0.0031613987
GSE28863_A3Up0.2531667129
GSE28863_A4Up0.0346978395
GSE48662Up0.4386222831

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-22-3pMIMAT0000077MIRT050468CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27181777Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease
27181777Conversely, loss of function of the gene GLIS2/NPHP7 causes progressive kidney atrophy, interstitial inflammatory infiltration, and fibrosis
27181777In contrast, loss of Glis2 is associated with activation of checkpoint kinase 1, stabilization of p53, and induction of cell senescence
27181777Interestingly, the cystic phenotype of Kif3a knockout mice is partially rescued by genetic ablation of Glis2 and pharmacological stabilization of p53
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