HCSGD entry for DGAT2

1. General information

Official gene symbol	DGAT2
Entrez ID	84649
Gene full name	diacylglycerol O-acyltransferase 2
Other gene symbols	ARAT GS1999FULL
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0003846	2-acylglycerol O-acyltransferase activity	IEA	molecular_function
GO:0004144	Diacylglycerol O-acyltransferase activity	IDA IEA	molecular_function
GO:0005739	Mitochondrion	IEA ISS	cellular_component
GO:0005783	Endoplasmic reticulum	IDA	cellular_component
GO:0005789	Endoplasmic reticulum membrane	TAS	cellular_component
GO:0005811	Lipid particle	IEA ISS	cellular_component
GO:0006071	Glycerol metabolic process	IEA	biological_process
GO:0006644	Phospholipid metabolic process	TAS	biological_process
GO:0016021	Integral component of membrane	IDA	cellular_component
GO:0016747	Transferase activity, transferring acyl groups other than amino-acyl groups	IEA	molecular_function
GO:0019432	Triglyceride biosynthetic process	IDA IEA TAS	biological_process
GO:0019915	Lipid storage	IEA ISS	biological_process
GO:0030176	Integral component of endoplasmic reticulum membrane	IC IEA ISS	cellular_component
GO:0034383	Low-density lipoprotein particle clearance	IEA ISS	biological_process
GO:0035336	Long-chain fatty-acyl-CoA metabolic process	IDA IEA	biological_process
GO:0035356	Cellular triglyceride homeostasis	IEA ISS	biological_process
GO:0036155	Acylglycerol acyl-chain remodeling	TAS	biological_process
GO:0042632	Cholesterol homeostasis	IEA ISS	biological_process
GO:0042803	Protein homodimerization activity	IEA ISS	molecular_function
GO:0044255	Cellular lipid metabolic process	TAS	biological_process
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0046339	Diacylglycerol metabolic process	IDA IEA	biological_process
GO:0046474	Glycerophospholipid biosynthetic process	TAS	biological_process
GO:0048471	Perinuclear region of cytoplasm	IEA ISS	cellular_component
GO:0050252	Retinol O-fatty-acyltransferase activity	IEA	molecular_function
GO:0055089	Fatty acid homeostasis	IEA ISS	biological_process
GO:0060613	Fat pad development	IEA ISS	biological_process
GO:0071400	Cellular response to oleic acid	IEA ISS	biological_process
GO:0097006	Regulation of plasma lipoprotein particle levels	ISS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.0002545800	0.9491806732	0.0444836601	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.4589372158
GSE13712_SHEAR	Up	0.3055322436
GSE13712_STATIC	Down	-0.0116218742
GSE19018	Up	0.1641727814
GSE19899_A1	Up	0.9302573569
GSE19899_A2	Up	5.4148428079
PubMed_21979375_A1	Up	4.9549020122
PubMed_21979375_A2	Up	4.6490587824
GSE35957	Up	0.3985862087
GSE36640	Down	-0.0017703868
GSE54402	Up	1.9647163911
GSE9593	Down	-0.1796340154
GSE43922	Up	1.6761343269
GSE24585	Up	0.7756866819
GSE37065	Down	-0.0070804015
GSE28863_A1	Down	-0.5252862721
GSE28863_A2	Up	0.2294080359
GSE28863_A3	Up	0.3564014526
GSE28863_A4	Down	-0.2623860014
GSE48662	Down	-0.0363995633

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results