HCSGD entry for AFAP1L2

1. General information

Official gene symbolAFAP1L2
Entrez ID84632
Gene full nameactin filament associated protein 1-like 2
Other gene symbolsKIAA1914 XB130
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006954Inflammatory responseIDAbiological_process
GO:0007346Regulation of mitotic cell cycleIDAbiological_process
GO:0016235AggresomeIDAcellular_component
GO:0017124SH3 domain bindingIPImolecular_function
GO:0030296Protein tyrosine kinase activator activityIDAmolecular_function
GO:0032675Regulation of interleukin-6 productionIDAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0042169SH2 domain bindingIPImolecular_function
GO:0042325Regulation of phosphorylationIDAbiological_process
GO:0042327Positive regulation of phosphorylationIDAbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0045742Positive regulation of epidermal growth factor receptor signaling pathwayIDAbiological_process
GO:0045859Regulation of protein kinase activityIDAbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0061098Positive regulation of protein tyrosine kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35010327500.71914110030.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1433364467
GSE13712_SHEARUp0.1456882680
GSE13712_STATICUp0.0340577026
GSE19018Down-0.4142493397
GSE19899_A1Up0.3605243623
GSE19899_A2Up0.4153127465
PubMed_21979375_A1Down-0.0956298610
PubMed_21979375_A2Up0.2841998263
GSE35957Up0.0449017815
GSE36640Down-0.9205440425
GSE54402Up0.2028027061
GSE9593Down-0.0083195039
GSE43922Up0.0160466568
GSE24585Up0.0679872865
GSE37065Down-0.0193890746
GSE28863_A1Down-0.0434072883
GSE28863_A2Down-0.1362485497
GSE28863_A3Up0.2455889940
GSE28863_A4Up0.0090701964
GSE48662Up0.0097361623

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT025412ProteomicsFunctional MTI (Weak)21566225
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.