HCSGD entry for CASR

1. General information

Official gene symbolCASR
Entrez ID846
Gene full namecalcium-sensing receptor
Other gene symbolsCAR EIG8 FHH FIH GPRC2A HHC HHC1 NSHPT PCAR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001503OssificationIEA TASbiological_process
GO:0002931Response to ischemiaIEAbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005178Integrin bindingIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005513Detection of calcium ionTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006816Calcium ion transportIEAbiological_process
GO:0006874Cellular calcium ion homeostasisIEA TASbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0007635Chemosensory behaviorTASbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008152Metabolic processTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0019808Polyamine bindingIEAmolecular_function
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0032024Positive regulation of insulin secretionIEAbiological_process
GO:0032781Positive regulation of ATPase activityIEAbiological_process
GO:0035729Cellular response to hepatocyte growth factor stimulusIEAbiological_process
GO:0042311VasodilationIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043679Axon terminusIEAcellular_component
GO:0044325Ion channel bindingIEAmolecular_function
GO:0045907Positive regulation of vasoconstrictionIEAbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIEAbiological_process
GO:0050927Positive regulation of positive chemotaxisIEAbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0060613Fat pad developmentIEAbiological_process
GO:0070509Calcium ion importIDAbiological_process
GO:0071305Cellular response to vitamin DIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:0071404Cellular response to low-density lipoprotein particle stimulusIEAbiological_process
GO:0071456Cellular response to hypoxiaIEAbiological_process
GO:0071774Response to fibroblast growth factorIEAbiological_process
GO:0090280Positive regulation of calcium ion importIEAbiological_process
GO:1901653Cellular response to peptideIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.64058066180.90930801260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0805103042
GSE13712_SHEARDown-0.0856949351
GSE13712_STATICDown-0.0699182508
GSE19018Up0.0705856051
GSE19899_A1Down-0.0109918093
GSE19899_A2Up0.0383284836
PubMed_21979375_A1Up0.0232016753
PubMed_21979375_A2Up0.0706298808
GSE35957Up0.2534370390
GSE36640Up0.0621509460
GSE54402Down-0.0088917535
GSE9593Up0.0820500188
GSE43922Up0.0157315334
GSE24585Up0.1018958691
GSE37065Up0.0045234314
GSE28863_A1Down-0.0584659166
GSE28863_A2Up0.0753633903
GSE28863_A3Up0.3545386492
GSE28863_A4Up0.1173868214
GSE48662Down-0.0566589359

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CinacalcetDB01012 APRD00872
751689DB05255 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-31-5pMIMAT0000089MIRT004597LacZ assayFunctional MTI20145132
hsa-miR-135b-5pMIMAT0000758MIRT007298Western blotFunctional MTI23340180
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24755407We have recently described an Epigenetic-Senescence-Signature that facilitates prediction of the state of cellular aging by analysis of DNAm at six CpG sites (associated with the genes GRM7, CASR, PRAMEF2, SELP, CASP14 and KRTAP13-3), but this has not yet been proven over subsequent passages and with MSCs isolated under good manufacturing practice (GMP) conditions
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