HCSGD entry for MAP1LC3A
1. General information
| Official gene symbol | MAP1LC3A |
|---|---|
| Entrez ID | 84557 |
| Gene full name | microtubule-associated protein 1 light chain 3 alpha |
| Other gene symbols | ATG8E LC3 LC3A MAP1ALC3 MAP1BLC3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000045 | Autophagic vacuole assembly | ISS | biological_process |
| GO:0000421 | Autophagic vacuole membrane | IEA | cellular_component |
| GO:0000422 | Mitochondrion degradation | IGI | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005543 | Phospholipid binding | IDA | molecular_function |
| GO:0005770 | Late endosome | IEA | cellular_component |
| GO:0005776 | Autophagic vacuole | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0008429 | Phosphatidylethanolamine binding | IDA | molecular_function |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0031090 | Organelle membrane | IDA | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5332019490 | 0.0472917138 | 0.9999902473 | 0.4079859718 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0783269703 |
| GSE13712_SHEAR | Down | -0.5913238802 |
| GSE13712_STATIC | Down | -0.4170635976 |
| GSE19018 | Up | 0.3443504098 |
| GSE19899_A1 | Down | -1.3025050061 |
| GSE19899_A2 | Down | -0.4571594761 |
| PubMed_21979375_A1 | Down | -0.1248681234 |
| PubMed_21979375_A2 | Down | -0.7700582870 |
| GSE35957 | Up | 0.7144945187 |
| GSE36640 | Up | 0.3887400213 |
| GSE54402 | Down | -0.1705441918 |
| GSE9593 | Up | 0.6843584272 |
| GSE43922 | Down | -0.5801875520 |
| GSE24585 | Down | -0.1291495949 |
| GSE37065 | Up | 0.0605828278 |
| GSE28863_A1 | Up | 0.0237839272 |
| GSE28863_A2 | Down | -0.3553734617 |
| GSE28863_A3 | Up | 0.2085967109 |
| GSE28863_A4 | Down | -0.1056311331 |
| GSE48662 | Up | 0.6656105740 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018831 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 12 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26930622 | We evaluated cell toxicity, apoptosis, viability, proliferation, senescence and autophagy in response to APAP (acetaminophen), cisplatin, dexamethasone, gentamicin, penicillin, neomycin, streptomycin, and tobramycin, at five different doses and two time-points (24 and 48 h), by flow cytometry techniques and caspase 3/7, MTT, Cytotoxicity, BrdU, Beclin1, LC3 and SA-beta-galactosidase assays |
| 26654219 | We reveal that the autophagy protein LC3/Atg8 directly interacts with the nuclear lamina protein LMNB1 (lamin B1), and binds to LMN/lamin-associated chromatin domains (LADs) |
| 26035971 | Since cell senescence process may be associated with changes in autophagy regulation, we analyzed the dynamics of one of the main autophagosome formation markers--protein LC3 |
| 25440825 | Autophagy was evaluated by image analysis techniques for the expression of light chain 3 (LC3) after immunohistochemical staining of LC3 rabbit polyclonal antibody and Western blot analysis; additionally, myocyte apoptosis was determined using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, 4',6-diamidino-2-phenylindole staining, and p53 immunohistochemical staining |
| 25440825 | RESULTS: LC3 expression was significantly increased at the renal pelvis (P < |
| 25440825 | A significant negative correlation was found between TUNEL and LC3 in all sections of the obstructed UPJ complex (P < |
| 25440825 | Proliferating cell nuclear antigen and LC3 were positively correlated in the renal pelvis and UPJ (P < |
| 25186470 | Knockdown of FOXO1 and FOXO1+3 resulted in significant reductions in levels of glutathione peroxidase 1 (GPX-1), catalase, light chain 3 (LC3), Beclin1, and sirtuin 1 (SIRT-1) proteins following treatment with tBHP |
| 25186470 | In contrast, the constitutive active form of FOXO3 increased cell viability while inducing GPX-1, Beclin1, and LC3 in response to tBHP |
| 25087910 | Autophagy in cells was examined by detecting for LC3, Beclin-1, m-TOR, and p70S6K, as well as by analyzing autophagosomes |
| 23231002 | The granular expression of mitochondrial antigens was colocalized with LC3 in damaged SBDs in PBC |
| 22613224 | Moreover, the senescence of HCT116 cells was accompanied by autophagy, that was confirmed by electron microscopy observations of autophagosomes in the curcumin-treated cells as well as LC3-II expression, punctue staining of LC3 and increased content of acidic vacuoles |
| 21989821 | RESULTS: The expression of LC3 was seen in coarse vesicles in the cytoplasm of bile ductular cells and significantly more frequently in PBC of both early and advanced stages when compared to control livers (p < 0 |
| 20212459 | We examined immunohistochemically the expression of microtubule-associated proteins-light chain 3beta (LC3), a marker of autophagy, in livers taken from the patients with PBC (n=37) and control livers (n=75) |
| 20212459 | The expression of LC3 was specifically seen in vesicles in BECs in the inflamed and damaged small bile ducts in PBC, when compared with non-inflamed small bile ducts in PBC and in control livers (P<0 |
| 20212459 | The expression of LC3 was closely related to the expression of cathepsin D, LAMP-1, and senescent markers |
| 18203850 | The cleaved microtubule-associated protein 1 light-chain 3 (LC3), a marker of autophagosome formation, was overexpressed within 24 h of GC treatment; however, by 4-5 days, it was nearly undetectable |
| 17635673 | Instead, we identified several indications of autophagy: electron microscopy showed typical autophagic vacuoles; acridine orange staining revealed acidic vesicular organelles; acidification of acidic vesicular organelles was prevented using bafilomycin A1; cells displayed arrest in G2/M; increased processing of LC3 occurred; vacuolation was prevented by the autophagy inhibitor 3-methyladenine; no caspase activation was detected |
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