HCSGD entry for CUL3

1. General information

Official gene symbolCUL3
Entrez ID8452
Gene full namecullin 3
Other gene symbolsCUL-3 PHA2E
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000090Mitotic anaphaseIMPbiological_process
GO:0000139Golgi membraneIMPcellular_component
GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0000910CytokinesisIMPbiological_process
GO:0001831Trophectodermal cellular morphogenesisIEAbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005827Polar microtubuleIDAcellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0006513Protein monoubiquitinationIDAbiological_process
GO:0006888ER to Golgi vesicle-mediated transportIDAbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007229Integrin-mediated signaling pathwayISSbiological_process
GO:0007369GastrulationIEAbiological_process
GO:0008054Cyclin catabolic processIDAbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016477Cell migrationIMPbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0017145Stem cell divisionISSbiological_process
GO:0030332Cyclin bindingIEAmolecular_function
GO:0031208POZ domain bindingIDAmolecular_function
GO:0031461Cullin-RING ubiquitin ligase complexIEAcellular_component
GO:0031463Cul3-RING ubiquitin ligase complexIDAcellular_component
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0032467Positive regulation of cytokinesisIMPbiological_process
GO:0035024Negative regulation of Rho protein signal transductionIMPbiological_process
GO:0040016Embryonic cleavageISSbiological_process
GO:0043149Stress fiber assemblyIMPbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0048208COPII vesicle coatingIMPbiological_process
GO:0051322AnaphaseIMPbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96729664150.06744550740.99999024730.4899872517

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0660432084
GSE13712_SHEARDown-0.5209711560
GSE13712_STATICDown-0.2886475603
GSE19018Down-0.3454049809
GSE19899_A1Down-0.0925722945
GSE19899_A2Down-0.4645196812
PubMed_21979375_A1Down-0.6593703259
PubMed_21979375_A2Down-0.2504783053
GSE35957Up0.0860594302
GSE36640Down-0.2032030006
GSE54402Down-0.1881935976
GSE9593Down-0.0422099186
GSE43922Down-0.0636280052
GSE24585Down-0.0038609408
GSE37065Up0.0238571504
GSE28863_A1Up0.3774887877
GSE28863_A2Up0.5795464040
GSE28863_A3Down-0.3183864086
GSE28863_A4Down-0.2021182839
GSE48662Down-0.1412027706

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004141MicroarrayFunctional MTI (Weak)16822819
hsa-let-7b-5pMIMAT0000063MIRT032239ProteomicsFunctional MTI (Weak)18668040
hsa-miR-18a-3pMIMAT0002891MIRT040752CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047577CLASHFunctional MTI (Weak)23622248
hsa-miR-99a-5pMIMAT0000097MIRT048703CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20978349The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells
20978349Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E
20978349Here we show that liver-specific ablation of Cul3 in mice results in the persistence and massive expansion of hepatic progenitor cells
20978349Simultaneous loss of Cul3 and p53 in hepatic progenitors turned these cells into highly malignant tumor-initiating cells that formed largely undifferentiated tumors in nude mice
20978349In addition, loss of Cul3 and p53 led to the formation of primary hepatocellular carcinomas
20978349Importantly, loss of Cul3 expression was also detected in a large series of human liver cancers and correlated directly with tumor de-differentiation
20978349The expression of Cul3 during hepatic differentiation therefore safeguards against the formation of progenitor cells that carry a great potential for transformation into tumor-initiating cells
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