HCSGD entry for MCM8
1. General information
| Official gene symbol | MCM8 |
|---|---|
| Entrez ID | 84515 |
| Gene full name | minichromosome maintenance complex component 8 |
| Other gene symbols | C20orf154 REC dJ967N21.5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000724 | Double-strand break repair via homologous recombination | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004386 | Helicase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0007292 | Female gamete generation | ISS | biological_process |
| GO:0048232 | Male gamete generation | ISS | biological_process |
| GO:0097362 | MCM8-MCM9 complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8916053493 | 0.0038049124 | 0.9999902473 | 0.1255030075 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5422354243 |
| GSE13712_SHEAR | Down | -0.0825232172 |
| GSE13712_STATIC | Up | 0.1170533794 |
| GSE19018 | Up | 0.0972121455 |
| GSE19899_A1 | Down | -0.1968546443 |
| GSE19899_A2 | Down | -1.2500090165 |
| PubMed_21979375_A1 | Down | -0.3137365219 |
| PubMed_21979375_A2 | Down | -0.9986448654 |
| GSE35957 | Down | -1.0048306223 |
| GSE36640 | Down | -2.1979275760 |
| GSE54402 | Down | -0.0875785562 |
| GSE9593 | Down | -0.8521806985 |
| GSE43922 | Down | -0.5306679772 |
| GSE24585 | Up | 0.0765573425 |
| GSE37065 | Down | -0.2041382296 |
| GSE28863_A1 | Down | -0.0304956373 |
| GSE28863_A2 | Up | 0.8106529296 |
| GSE28863_A3 | Down | -0.4374058759 |
| GSE28863_A4 | Up | 0.3590026835 |
| GSE48662 | Down | -1.0897783565 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016553 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020992 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048686 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
