HCSGD entry for CUL4A
1. General information
| Official gene symbol | CUL4A |
|---|---|
| Entrez ID | 8451 |
| Gene full name | cullin 4A |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0031464 | Cul4A-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0051246 | Regulation of protein metabolic process | IEA | biological_process |
| GO:0080008 | Cul4-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
| GO:1900087 | Positive regulation of G1/S transition of mitotic cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3486767828 | 0.6847697922 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1184811594 |
| GSE13712_SHEAR | Up | 0.5323459034 |
| GSE13712_STATIC | Up | 0.3934104408 |
| GSE19018 | Up | 0.2706390087 |
| GSE19899_A1 | Down | -0.2668084306 |
| GSE19899_A2 | Up | 0.2175311825 |
| PubMed_21979375_A1 | Down | -0.4243735179 |
| PubMed_21979375_A2 | Up | 0.1484930296 |
| GSE35957 | Up | 0.0172870336 |
| GSE36640 | Down | -0.0093068489 |
| GSE54402 | Down | -0.1338065187 |
| GSE9593 | Up | 0.0367349647 |
| GSE43922 | Down | -0.2701877236 |
| GSE24585 | Down | -0.1084222647 |
| GSE37065 | Up | 0.0170860413 |
| GSE28863_A1 | Up | 0.3098514067 |
| GSE28863_A2 | Up | 0.1778319869 |
| GSE28863_A3 | Down | -0.0497482813 |
| GSE28863_A4 | Up | 0.0973779936 |
| GSE48662 | Down | -0.3135154517 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027107 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031821 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039946 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041473 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046251 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048313 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050685 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19208841 | We showed that CUL4A directly binds to p16 and that silencing DDB1 blocks Ras-induced p16 activation |
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