HCSGD entry for CUL4B
1. General information
| Official gene symbol | CUL4B |
|---|---|
| Entrez ID | 8450 |
| Gene full name | cullin 4B |
| Other gene symbols | MRXHF2 MRXS15 MRXSC SFM2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007049 | Cell cycle | NAS | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0031461 | Cullin-RING ubiquitin ligase complex | IEA | cellular_component |
| GO:0031465 | Cul4B-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0045732 | Positive regulation of protein catabolic process | IEA | biological_process |
| GO:1900087 | Positive regulation of G1/S transition of mitotic cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9306763193 | 0.0075577828 | 0.9999902473 | 0.1736590750 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1724387221 |
| GSE13712_SHEAR | Up | 0.6855144014 |
| GSE13712_STATIC | Up | 0.3147003657 |
| GSE19018 | Up | 0.4332943356 |
| GSE19899_A1 | Down | -0.6334769587 |
| GSE19899_A2 | Down | -0.9757142613 |
| PubMed_21979375_A1 | Down | -1.5479138685 |
| PubMed_21979375_A2 | Down | -0.5736948946 |
| GSE35957 | Down | -0.2030542557 |
| GSE36640 | Down | -0.4966811564 |
| GSE54402 | Down | -0.2840612824 |
| GSE9593 | Down | -0.2420176262 |
| GSE43922 | Down | -0.7619948605 |
| GSE24585 | Down | -0.4908585611 |
| GSE37065 | Up | 0.1298885912 |
| GSE28863_A1 | Down | -0.1830280004 |
| GSE28863_A2 | Down | -0.3961607733 |
| GSE28863_A3 | Down | -0.5841322884 |
| GSE28863_A4 | Down | -0.0721191067 |
| GSE48662 | Down | -0.5139410982 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001556 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023489 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037054 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046192 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25464270 | CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop |
| 25464270 | We here report that a p53-ROS positive feedback loop drives a senescence program in normal human fibroblasts (NHFs) and this senescence-driving loop is negatively regulated by CUL4B |
| 25464270 | CUL4B, which can assemble various ubiquitin E3 ligases, was found to be downregulated in stress-induced senescent cells, but not in replicative senescent cells |
| 25464270 | We observed that p53-dependent ROS production was significantly augmented and stress-induced senescence was greatly enhanced when CUL4B was absent or depleted |
| 25464270 | Ectopic expression of CUL4B, on the other hand, blunted p53 activation, reduced ROS production, and attenuated cellular senescence in cells treated with H2O2 |
| 25464270 | CUL4B was shown to promote p53 ubiquitination and proteosomal degradation in NHFs exposed to oxidative stress, thus dampening the p53-dependent cellular senescence |
| 25464270 | Together, our results established a critical role of CUL4B in negatively regulating the p53-ROS positive feedback loop that drives cellular senescence |
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