HCSGD entry for SLX4
1. General information
| Official gene symbol | SLX4 |
|---|---|
| Entrez ID | 84464 |
| Gene full name | SLX4 structure-specific endonuclease subunit |
| Other gene symbols | BTBD12 FANCP MUS312 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000724 | Double-strand break repair via homologous recombination | IMP | biological_process |
| GO:0000737 | DNA catabolic process, endonucleolytic | IDA | biological_process |
| GO:0000784 | Nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006281 | DNA repair | IMP | biological_process |
| GO:0006289 | Nucleotide-excision repair | IMP | biological_process |
| GO:0008047 | Enzyme activator activity | IDA | molecular_function |
| GO:0008821 | Crossover junction endodeoxyribonuclease activity | IDA | molecular_function |
| GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing | IMP | biological_process |
| GO:0017108 | 5'-flap endonuclease activity | IDA | molecular_function |
| GO:0033557 | Slx1-Slx4 complex | IDA | cellular_component |
| GO:0043085 | Positive regulation of catalytic activity | IDA | biological_process |
| GO:0048257 | 3'-flap endonuclease activity | IDA | molecular_function |
| GO:0048476 | Holliday junction resolvase complex | IDA | cellular_component |
| GO:0050790 | Regulation of catalytic activity | IDA | biological_process |
| GO:0070522 | ERCC4-ERCC1 complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1659959614 | 0.9253367919 | 0.8057632830 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0374380780 |
| GSE13712_SHEAR | Up | 0.1971457928 |
| GSE13712_STATIC | Up | 0.1689490309 |
| GSE19018 | Up | 0.0169919580 |
| GSE19899_A1 | Up | 0.1976455236 |
| GSE19899_A2 | Up | 0.2921134045 |
| PubMed_21979375_A1 | Up | 0.5536378479 |
| PubMed_21979375_A2 | Up | 0.5752307349 |
| GSE35957 | Down | -0.1531049942 |
| GSE36640 | Up | 0.0026373413 |
| GSE54402 | Up | 0.1492398712 |
| GSE9593 | Down | -0.1387446706 |
| GSE43922 | Up | 0.2936573073 |
| GSE24585 | Down | -0.1876171251 |
| GSE37065 | Down | -0.1250248368 |
| GSE28863_A1 | Up | 0.1113822484 |
| GSE28863_A2 | Up | 0.3370422538 |
| GSE28863_A3 | Up | 0.2562563235 |
| GSE28863_A4 | Up | 0.0576490403 |
| GSE48662 | Down | -0.3481401093 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-340-5p | MIMAT0004692 | MIRT019533 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028283 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037462 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
