HCSGD entry for DOT1L
1. General information
| Official gene symbol | DOT1L |
|---|---|
| Entrez ID | 84444 |
| Gene full name | DOT1-like histone H3K79 methyltransferase |
| Other gene symbols | DOT1 KMT4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0018022 | Peptidyl-lysine methylation | IDA | biological_process |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IDA IEA | molecular_function |
| GO:0034968 | Histone lysine methylation | IDA | biological_process |
| GO:0046425 | Regulation of JAK-STAT cascade | IDA | biological_process |
| GO:2000677 | Regulation of transcription regulatory region DNA binding | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1386174689 | 0.8769365640 | 0.7488236972 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0608210589 |
| GSE13712_SHEAR | Up | 0.2037825181 |
| GSE13712_STATIC | Down | -0.0695884567 |
| GSE19018 | Down | -0.0066373960 |
| GSE19899_A1 | Down | -0.0500314190 |
| GSE19899_A2 | Up | 0.2391574463 |
| PubMed_21979375_A1 | Up | 0.5875750550 |
| PubMed_21979375_A2 | Up | 0.4117369334 |
| GSE35957 | Up | 0.0348581902 |
| GSE36640 | Down | -0.4207487958 |
| GSE54402 | Up | 0.2242210738 |
| GSE9593 | Down | -0.4120768269 |
| GSE43922 | Up | 0.4618822190 |
| GSE24585 | Up | 0.8234472912 |
| GSE37065 | Down | -0.0497504529 |
| GSE28863_A1 | Down | -0.0215408332 |
| GSE28863_A2 | Down | -0.0425106183 |
| GSE28863_A3 | Up | 0.1526328688 |
| GSE28863_A4 | Up | 0.0245685063 |
| GSE48662 | Up | 0.1888024493 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049038 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051846 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
