HCSGD entry for NCK2

1. General information

Official gene symbolNCK2
Entrez ID8440
Gene full nameNCK adaptor protein 2
Other gene symbolsGRB4 NCKbeta
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmNAScellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006417Regulation of translationIEAbiological_process
GO:0007015Actin filament organizationIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007172Signal complex assemblyNASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007176Regulation of epidermal growth factor-activated receptor activityTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008093Cytoskeletal adaptor activityNASmolecular_function
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0012506Vesicle membraneIEAcellular_component
GO:0016477Cell migrationIEAbiological_process
GO:0019887Protein kinase regulator activityIEAmolecular_function
GO:0030032Lamellipodium assemblyIEAbiological_process
GO:0030159Receptor signaling complex scaffold activityNASmolecular_function
GO:0030838Positive regulation of actin filament polymerizationIMPbiological_process
GO:0042102Positive regulation of T cell proliferationIMPbiological_process
GO:0042110T cell activationNASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94529359450.11142665170.99999024730.6394347864

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1830004120
GSE13712_SHEARDown-0.2407830213
GSE13712_STATICDown-0.1869806652
GSE19018Down-0.1132205402
GSE19899_A1Down-0.2805872802
GSE19899_A2Up0.0275465852
PubMed_21979375_A1Down-0.3442507481
PubMed_21979375_A2Up0.2005768237
GSE35957Down-0.2302278065
GSE36640Up0.0302098591
GSE54402Up0.1482330165
GSE9593Up0.1624438403
GSE43922Down-0.0225169837
GSE24585Down-0.4801099232
GSE37065Down-0.2580421082
GSE28863_A1Down-0.1201638964
GSE28863_A2Up0.0972944323
GSE28863_A3Up0.1301250003
GSE28863_A4Down-0.0390123142
GSE48662Down-0.0778592586

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT021929MicroarrayFunctional MTI (Weak)17612493
hsa-miR-877-3pMIMAT0004950MIRT036831CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.