HCSGD entry for SDPR
1. General information
| Official gene symbol | SDPR |
|---|---|
| Entrez ID | 8436 |
| Gene full name | serum deprivation response |
| Other gene symbols | CAVIN2 PS-p68 SDR cavin-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001786 | Phosphatidylserine binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005543 | Phospholipid binding | TAS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005901 | Caveola | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8998296417 | 0.0006093234 | 0.9999902473 | 0.0463549133 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6458886254 |
| GSE13712_SHEAR | Down | -0.2007126494 |
| GSE13712_STATIC | Down | -0.3052435098 |
| GSE19018 | Down | -0.0074791021 |
| GSE19899_A1 | Down | -0.7273619361 |
| GSE19899_A2 | Down | -1.7121749393 |
| PubMed_21979375_A1 | Down | -2.3177248901 |
| PubMed_21979375_A2 | Down | -1.1713026126 |
| GSE35957 | Up | 2.8893163674 |
| GSE36640 | Up | 0.1733889784 |
| GSE54402 | Down | -4.0174003307 |
| GSE9593 | Down | -0.0361153584 |
| GSE43922 | Down | -0.8466860014 |
| GSE24585 | Down | -0.0258576512 |
| GSE37065 | Down | -0.0613044641 |
| GSE28863_A1 | Down | -0.7519788093 |
| GSE28863_A2 | Down | -0.8441178672 |
| GSE28863_A3 | Down | -0.0918510507 |
| GSE28863_A4 | Up | 0.1239432589 |
| GSE48662 | Down | -0.1955516065 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023867 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25407919 | Senescent EC induced by either the overexpression of ARHGAP18/SENEX or by H(2)O(2) showed significantly increased numbers of caveolae and associated proteins Caveolin-1, cavin-1 and cavin-2 |
| 23949429 | The promoter for the Sdpr gene was determined to be progressively hypomethylated with age |
| 23949429 | To explore this relationship further, we cultured isolated SP-HSC in the presence of 5-aza-deoxycytdine and demonstrated a negative correlation between Sdpr promoter methylation and gene expression |
| 23949429 | We report that DNA methylation patterns are well preserved during hematopoietic stem cell aging, confirm that PCRC2 targets are increasingly methylated with age, and suggest that SDPR expression changes with age in HSCs may be regulated via age-based alterations in DNA methylation |
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