HCSGD entry for ING5
1. General information
| Official gene symbol | ING5 |
|---|---|
| Entrez ID | 84289 |
| Gene full name | inhibitor of growth family, member 5 |
| Other gene symbols | p28ING5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006260 | DNA replication | IDA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006473 | Protein acetylation | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IDA IGI | biological_process |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IGI | biological_process |
| GO:0043966 | Histone H3 acetylation | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045926 | Negative regulation of growth | IDA | biological_process |
| GO:0070776 | MOZ/MORF histone acetyltransferase complex | IDA | cellular_component |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6388312260 | 0.6731377911 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0290199670 |
| GSE13712_SHEAR | Up | 0.1809866269 |
| GSE13712_STATIC | Up | 0.1299691079 |
| GSE19018 | Up | 0.0189481422 |
| GSE19899_A1 | Down | -0.0830572323 |
| GSE19899_A2 | Up | 0.0536554488 |
| PubMed_21979375_A1 | Down | -0.4141100962 |
| PubMed_21979375_A2 | Down | -0.4499048968 |
| GSE35957 | Down | -0.0698215878 |
| GSE36640 | Down | -0.3114849508 |
| GSE54402 | Up | 0.2315065524 |
| GSE9593 | Down | -0.1157351803 |
| GSE43922 | Up | 0.0545615370 |
| GSE24585 | Up | 0.0887953074 |
| GSE37065 | Up | 0.0070405532 |
| GSE28863_A1 | Up | 0.2011798989 |
| GSE28863_A2 | Up | 0.1161626348 |
| GSE28863_A3 | Up | 0.0524387490 |
| GSE28863_A4 | Up | 0.1660302800 |
| GSE48662 | Down | -0.0085229083 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24254310 | In these studies, inhibitor of growth protein 5 (ING5) and various fragments of it were overexpressed in the human tongue squamous cell carcinoma cell line, HSC-3 |
| 24254310 | The roles of ING5 in HSC-3 cells were then identified in vitro |
| 24254310 | Our results indicate that intact ING5 can inhibit proliferation and induce apoptosis in HSC-3 cells |
| 24254310 | Moreover, two truncated fragments of ING5 (aa 1-184 and aa 107-226) can induce cellular senescence |
| 24254310 | In these assays, two truncated fragments of ING5 were found to inhibit the cyclin E and CDK2 expression |
| 24254310 | These results are consistent with the S phase arrest observed with the overexpression of truncated ING5 |
| 21767350 | The Inhibitor of Growth (ING) proteins represent a type II tumor suppressor family comprising five conserved genes, ING1 to ING5 |
| 21767350 | While ING1, ING2 and ING3 proteins are stable components of the mSIN3a-HDAC complexes, the association of ING1, ING4 and ING5 with HAT protein complexes was also reported |
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