HCSGD entry for CASP9

1. General information

Official gene symbolCASP9
Entrez ID842
Gene full namecaspase 9, apoptosis-related cysteine peptidase
Other gene symbolsAPAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004197Cysteine-type endopeptidase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolIDA IEA TAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006915Apoptotic processIEA TASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDA IEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0008047Enzyme activator activityTASmolecular_function
GO:0008233Peptidase activityIDAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIMPbiological_process
GO:0008635Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cTASbiological_process
GO:0009411Response to UVIEAbiological_process
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0019901Protein kinase bindingIDAmolecular_function
GO:0030220Platelet formationTASbiological_process
GO:0032025Response to cobalt ionIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0034349Glial cell apoptotic processIEAbiological_process
GO:0034644Cellular response to UVIDAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042770Signal transduction in response to DNA damageIDAbiological_process
GO:0042981Regulation of apoptotic processIEA TASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043293ApoptosomeIDAcellular_component
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046677Response to antibioticIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0071549Cellular response to dexamethasone stimulusIEAbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:2001020Regulation of response to DNA damage stimulusIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13051992330.89217488700.73374944471.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0857318879
GSE13712_SHEARUp0.3476060764
GSE13712_STATICUp0.3817753667
GSE19018Up0.1690628598
GSE19899_A1Up0.0325970199
GSE19899_A2Up0.6475398515
PubMed_21979375_A1Up0.6799438120
PubMed_21979375_A2Up0.2205824006
GSE35957Up0.0591891740
GSE36640Up0.0886573959
GSE54402Up0.1895777811
GSE9593Up0.0455671169
GSE43922Up0.2562374677
GSE24585Up0.3149713735
GSE37065Down-0.0904077391
GSE28863_A1Down-0.0193769948
GSE28863_A2Down-0.0817272652
GSE28863_A3Down-0.4443510297
GSE28863_A4Down-0.1903336133
GSE48662Down-0.3062615614

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-133a-3pMIMAT0000427MIRT001986Luciferase reporter assayFunctional MTI17715156
hsa-let-7a-5pMIMAT0000062MIRT005294Western blotNon-Functional MTI18758960
hsa-miR-193b-3pMIMAT0002819MIRT016408MicroarrayFunctional MTI (Weak)20304954
hsa-miR-7-5pMIMAT0000252MIRT025767MicroarrayFunctional MTI (Weak)19073608
hsa-miR-26b-5pMIMAT0000083MIRT029244MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 12 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27212655This resistance occurred via caspase-9 and caspase-3 rather than via caspase-8
26515130Ad5-CMV-CCN1 induced HSC apoptosis that was evident by proteolytic cleavage of caspase-12, caspase-9 and the executor caspase-3 and positive TUNEL stain
25962658Quantitative analysis of the expression of caspase 3 and caspase 9 in different types of atherosclerotic lesions in the human aorta
25962658This study was undertaken to evaluate the levels of the expression of key apoptosis-related genes, namely, caspase 3 (CASP3) and caspase 9 (CASP9) in the normal (non-atherosclerotic) intima of the human aorta in comparison with those in different types of atherosclerotic lesions
25962658The study revealed that the expressions of CASP3 and CASP9 genes were changed in different types of atherosclerotic lesions in course of the progression of the disease, but not in a unanimous way
25962658Our study provides novel quantitative data on the expression of CASP3 and CASP9 genes in different atherosclerotic lesions in the human aorta and thus, might assist in better understanding of the processes occurring during the development of lesions in human atherogenesis
25852816Cell senescence was found to appear prematurely in DS cells as shown by SA-beta-Gal assay and p21 assessment, though not apoptosis, as neither p53 nor the proapoptotic proteins cytochrome c and caspase 9 were altered in T21F
24782600Activation of egr-1, in turn, upregulates the dual specificity phosphatase, phosphatase and tensin homologue deleted on chromosome ten (PTEN) resulting in activation of pro-apoptotic caspase-3 and caspase-9 and reduced expression of the anti-apoptosis protein, survivin
24535104In the present study, RC-6 induced cytotoxicity in NT2 cells (a human embryonal carcinoma cell line) and our studies showed that RC-6 can exert anticancer effects and induce caspase-9 and -3 activities
23238821The apoptosis and senescence of NP cells was investigated by terminal deoxyribonucleotidyl transferase (TDT)-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay, immunohistochemistry, and Western blot for caspase3, caspase8, caspase9, and p16lnk4A (increased in cellular senescence)
22919441Both SIPS and senescent HDFs shared similar apoptotic changes such as increased Annexin V-FITC positive cells, increased cytochrome c release and increased activation of caspase-9 and caspase-3 (P < 0
22919441GTT treatment resulted in a significant reduction of Annexin V-FITC positive cells, inhibited cytochrome c release and decreased activation of caspase-9 and caspase-3 (P < 0
22919441These findings suggested that GTT inhibits apoptosis by modulating the upstream apoptosis cascade, causing the inhibition of cytochrome c release from the mitochondria with concomitant suppression of caspase-9 and caspase-3 activation
18694296Both SAHA and MS-275 induced an arrest in the cell cycle along with the induction of apoptotic pathways as evidenced by flow cytometry, annexin assay, detection of activated caspase 9, and molecular analysis of Bax/Bcl-2 expression
18313665Caspase 9 inhibition protected TRAIL-treated cells from senescence, whereas inhibition of caspases 1 and 8 increased the yield of SLP cells
17145870Here, we report that IR induced caspase-9 and caspase-3 activation and subsequent apoptosis only in p21-deficient colon carcinoma cells, whereas similar treated wild-type cells were permanently arrested in the G(2)-M phase, correlating with the induction of cellular senescence
17145870Interestingly, activation of the mitochondrial pathway, including caspase-2 processing, depolarization of the outer mitochondrial membrane, and cytochrome c release, was achieved by IR in both cell lines, indicating that p21 inhibits an event downstream of mitochondria but preceding caspase-9 activation
17145870In addition, p21 did neither interact with caspase-3 or caspase-9, suggesting that these events are not required for the observed protection
16325773Caspase-3 and caspase-9 activity was lower in Klotho-treated HUVEC than in control cells
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