HCSGD entry for ZNRF3
1. General information
| Official gene symbol | ZNRF3 |
|---|---|
| Entrez ID | 84133 |
| Gene full name | zinc and ring finger 3 |
| Other gene symbols | BK747E2.3 RNF203 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005109 | Frizzled binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0038018 | Wnt receptor catabolic process | IMP | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IEA | biological_process |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | IEA | biological_process |
| GO:0072089 | Stem cell proliferation | ISS | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IMP | biological_process |
| GO:2000051 | Negative regulation of non-canonical Wnt signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0767408723 | 0.7397382318 | 0.5857999131 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1502625642 |
| GSE13712_SHEAR | Down | -0.0177315150 |
| GSE13712_STATIC | Up | 0.9152353514 |
| GSE19018 | Down | -0.9503847280 |
| GSE19899_A1 | Up | 0.3382103638 |
| GSE19899_A2 | Down | -0.0986161374 |
| PubMed_21979375_A1 | Up | 0.8792856685 |
| PubMed_21979375_A2 | Up | 0.1570802626 |
| GSE35957 | Down | -0.1422201864 |
| GSE36640 | Up | 0.0584939396 |
| GSE54402 | Up | 0.6940370457 |
| GSE9593 | Up | 0.3031153219 |
| GSE43922 | Up | 0.0557858718 |
| GSE24585 | Down | -0.1203164720 |
| GSE37065 | Down | -0.0428708248 |
| GSE28863_A1 | Up | 0.1562611114 |
| GSE28863_A2 | Up | 0.1660502732 |
| GSE28863_A3 | Up | 0.0624954651 |
| GSE28863_A4 | Up | 0.0039067782 |
| GSE48662 | Down | -0.1787438345 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027017 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031450 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042789 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
