HCSGD entry for EEA1
1. General information
| Official gene symbol | EEA1 |
|---|---|
| Entrez ID | 8411 |
| Gene full name | early endosome antigen 1 |
| Other gene symbols | MST105 MSTP105 ZFYVE2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | NAS | molecular_function |
| GO:0005545 | 1-phosphatidylinositol binding | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005969 | Serine-pyruvate aminotransferase complex | IEA | cellular_component |
| GO:0006897 | Endocytosis | IMP | biological_process |
| GO:0006906 | Vesicle fusion | IMP | biological_process |
| GO:0008270 | Zinc ion binding | TAS | molecular_function |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016189 | Synaptic vesicle to endosome fusion | TAS | biological_process |
| GO:0019897 | Extrinsic component of plasma membrane | IDA | cellular_component |
| GO:0030742 | GTP-dependent protein binding | IDA | molecular_function |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0045022 | Early endosome to late endosome transport | NAS | biological_process |
| GO:0055037 | Recycling endosome | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0796677710 | 0.7053763611 | 0.5942918957 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0947508818 |
| GSE13712_SHEAR | Up | 0.2269715020 |
| GSE13712_STATIC | Up | 0.2615285093 |
| GSE19018 | Up | 0.0553178976 |
| GSE19899_A1 | Down | -0.2357771924 |
| GSE19899_A2 | Down | -0.1063549538 |
| PubMed_21979375_A1 | Down | -0.1952116513 |
| PubMed_21979375_A2 | Up | 0.6574581711 |
| GSE35957 | Up | 0.3862142889 |
| GSE36640 | Up | 0.7094598027 |
| GSE54402 | Down | -0.1097736437 |
| GSE9593 | Up | 0.2974355232 |
| GSE43922 | Down | -0.1468269379 |
| GSE24585 | Down | -0.3179950350 |
| GSE37065 | Down | -0.1841908301 |
| GSE28863_A1 | Up | 0.6420246764 |
| GSE28863_A2 | Up | 0.5760991494 |
| GSE28863_A3 | Down | -0.2146403144 |
| GSE28863_A4 | Up | 0.1579674910 |
| GSE48662 | Down | -0.0684694608 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Inositol 1,3-Bisphosphate | DB02942 | EXPT01941 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018646 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-375 | MIMAT0000728 | MIRT020049 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023050 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026762 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
