HCSGD entry for OBSCN


1. General information

Official gene symbolOBSCN
Entrez ID84033
Gene full nameobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Other gene symbolsARHGEF30 UNC89
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0008307Structural constituent of muscleNASmolecular_function
GO:0030016MyofibrilNAScellular_component
GO:0030018Z discISScellular_component
GO:0030506Ankyrin bindingIPImolecular_function
GO:0031430M bandISScellular_component
GO:0031432Titin bindingIPImolecular_function
GO:0036309Protein localization to M-bandISSbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0045214Sarcomere organizationTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44536671860.95386867520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0049239690
GSE13712_SHEARUp0.1834967967
GSE13712_STATICUp0.0346612762
GSE19018Up0.0493945553
GSE19899_A1Up0.0252975213
GSE19899_A2Up0.1010611022
PubMed_21979375_A1Down-0.0063432805
PubMed_21979375_A2Up0.0836376159
GSE35957Up0.1462381902
GSE36640Up0.1597797413
GSE54402Up0.0140527074
GSE9593Down-0.0200105580
GSE43922Up0.0274089756
GSE24585Up0.2457707158
GSE37065Down-0.0188514990
GSE28863_A1Down-0.0859127495
GSE28863_A2Up0.0608077523
GSE28863_A3Up0.2779980500
GSE28863_A4Up0.0693051987
GSE48662Up0.0917987481

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020811ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.