HCSGD entry for CASP7
1. General information
| Official gene symbol | CASP7 |
|---|---|
| Entrez ID | 840 |
| Gene full name | caspase 7, apoptosis-related cysteine peptidase |
| Other gene symbols | CASP-7 CMH-1 ICE-LAP3 LICE2 MCH3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001836 | Release of cytochrome c from mitochondria | IEA | biological_process |
| GO:0004190 | Aspartic-type endopeptidase activity | IEA | molecular_function |
| GO:0004197 | Cysteine-type endopeptidase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | IDA IEA TAS | cellular_component |
| GO:0006508 | Proteolysis | IDA IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | TAS | molecular_function |
| GO:0008635 | Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c | TAS | biological_process |
| GO:0009411 | Response to UV | IEA | biological_process |
| GO:0016485 | Protein processing | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0097153 | Cysteine-type endopeptidase activity involved in apoptotic process | IEA | molecular_function |
| GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
| GO:0097194 | Execution phase of apoptosis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0811235705 | 0.4343079100 | 0.6006338959 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2194937234 |
| GSE13712_SHEAR | Up | 0.2089876034 |
| GSE13712_STATIC | Up | 0.2891234320 |
| GSE19018 | Down | -0.7812370865 |
| GSE19899_A1 | Up | 0.3623278273 |
| GSE19899_A2 | Up | 0.1616311382 |
| PubMed_21979375_A1 | Up | 0.5151311279 |
| PubMed_21979375_A2 | Up | 0.9263532244 |
| GSE35957 | Down | -0.6676989809 |
| GSE36640 | Up | 0.1274843390 |
| GSE54402 | Up | 0.4964188869 |
| GSE9593 | Down | -0.4024846197 |
| GSE43922 | Up | 0.1219675424 |
| GSE24585 | Up | 0.1004718577 |
| GSE37065 | Up | 0.1527959640 |
| GSE28863_A1 | Up | 0.1160943989 |
| GSE28863_A2 | Up | 0.4378291085 |
| GSE28863_A3 | Down | -0.6108213552 |
| GSE28863_A4 | Down | -0.1116020977 |
| GSE48662 | Down | -0.3064812927 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020444 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021838 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023343 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024257 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026826 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030234 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-484 | MIMAT0002174 | MIRT042101 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 18056640 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26029164 | The mechanism study showed that CSIG modulated the mRNA half-life of Cdc14B, CASP7, and CREBL2 |
| 21784712 | Important findings included significant upregulation of p53 and several proapoptotic genes (including apoptosis-inducing factor, mitochondrion-associated 1, BCL2-like 11 [an apoptosis facilitator]; caspase 7 apoptosis-related cysteine peptidase; proteasome 26S subunit nonadenosine triphosphatase 10, programmed cell death 6, and reticulon 3) |
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