HCSGD entry for PLA2G6

1. General information

Official gene symbol	PLA2G6
Entrez ID	8398
Gene full name	phospholipase A2, group VI (cytosolic, calcium-independent)
Other gene symbols	CaI-PLA2 GVI INAD1 IPLA2-VIA NBIA2 NBIA2A NBIA2B PARK14 PLA2 PNPLA9 iPLA2 iPLA2beta
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001934	Positive regulation of protein phosphorylation	IEA	biological_process
GO:0004623	Phospholipase A2 activity	TAS	molecular_function
GO:0005516	Calmodulin binding	IEA	molecular_function
GO:0005737	Cytoplasm	IDA	cellular_component
GO:0005739	Mitochondrion	IEA	cellular_component
GO:0005813	Centrosome	IDA	cellular_component
GO:0005829	Cytosol	IEA TAS	cellular_component
GO:0006629	Lipid metabolic process	IEA	biological_process
GO:0006644	Phospholipid metabolic process	TAS	biological_process
GO:0006935	Chemotaxis	IEA	biological_process
GO:0007204	Positive regulation of cytosolic calcium ion concentration	IEA	biological_process
GO:0007613	Memory	IEA	biological_process
GO:0008219	Cell death	IEA	biological_process
GO:0014832	Urinary bladder smooth muscle contraction	IEA	biological_process
GO:0016020	Membrane	IEA	cellular_component
GO:0016042	Lipid catabolic process	IEA	biological_process
GO:0016787	Hydrolase activity	IEA	molecular_function
GO:0032049	Cardiolipin biosynthetic process	IMP	biological_process
GO:0034976	Response to endoplasmic reticulum stress	IEA	biological_process
GO:0035774	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA	biological_process
GO:0035965	Cardiolipin acyl-chain remodeling	TAS	biological_process
GO:0036151	Phosphatidylcholine acyl-chain remodeling	TAS	biological_process
GO:0036152	Phosphatidylethanolamine acyl-chain remodeling	TAS	biological_process
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS	biological_process
GO:0043008	ATP-dependent protein binding	IEA	molecular_function
GO:0044281	Small molecule metabolic process	TAS	biological_process
GO:0045087	Innate immune response	TAS	biological_process
GO:0045909	Positive regulation of vasodilation	IEA	biological_process
GO:0045921	Positive regulation of exocytosis	IEA	biological_process
GO:0046474	Glycerophospholipid biosynthetic process	TAS	biological_process
GO:0047499	Calcium-independent phospholipase A2 activity	IEA	molecular_function
GO:0051967	Negative regulation of synaptic transmission, glutamatergic	IEA	biological_process
GO:0060135	Maternal process involved in female pregnancy	IEA	biological_process
GO:0090037	Positive regulation of protein kinase C signaling	IEA	biological_process
GO:0090200	Positive regulation of release of cytochrome c from mitochondria	IEA	biological_process
GO:0090238	Positive regulation of arachidonic acid secretion	IEA	biological_process
GO:1901339	Regulation of store-operated calcium channel activity	IEA	biological_process
GO:2000304	Positive regulation of ceramide biosynthetic process	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.7047539455	0.8535783861	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0386038543
GSE13712_SHEAR	Down	-0.1573192313
GSE13712_STATIC	Down	-0.1141316318
GSE19018	Up	0.1746754294
GSE19899_A1	Up	0.0850722657
GSE19899_A2	Up	0.1377360005
PubMed_21979375_A1	Down	-0.0154843788
PubMed_21979375_A2	Up	0.0207266381
GSE35957	Up	0.0658899296
GSE36640	Up	0.0409843551
GSE54402	Down	-0.1132443329
GSE9593	Down	-0.0416879975
GSE43922	Up	0.0231250981
GSE24585	Up	0.1716737855
GSE37065	Down	-0.0969859819
GSE28863_A1	Up	0.1078476687
GSE28863_A2	Down	-0.0987991797
GSE28863_A3	Up	0.2549662818
GSE28863_A4	Down	-0.0002277953
GSE48662	Up	0.1628776036

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for PLA2G6

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )