HCSGD entry for PIP5K1A

1. General information

Official gene symbolPIP5K1A
Entrez ID8394
Gene full namephosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005847MRNA cleavage and polyadenylation specificity factor complexIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006650Glycerophospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006909PhagocytosisTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008654Phospholipid biosynthetic processIDAbiological_process
GO:0010761Fibroblast migrationIEAbiological_process
GO:0016307Phosphatidylinositol phosphate kinase activityIEAmolecular_function
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activityIDA IEA TASmolecular_function
GO:0016477Cell migrationNASbiological_process
GO:0016607Nuclear speckIDA TAScellular_component
GO:0019900Kinase bindingIDAmolecular_function
GO:0030027LamellipodiumIDAcellular_component
GO:0030216Keratinocyte differentiationTASbiological_process
GO:0031532Actin cytoskeleton reorganizationIMPbiological_process
GO:0032587Ruffle membraneIDA IEAcellular_component
GO:0032863Activation of Rac GTPase activityIMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationIDA TASbiological_process
GO:0048041Focal adhesion assemblyIMPbiological_process
GO:0060326Cell chemotaxisIMPbiological_process
GO:0072661Protein targeting to plasma membraneIMPbiological_process
GO:0097178Ruffle assemblyIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35276726190.37139159990.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0311212681
GSE13712_SHEARUp0.2636160330
GSE13712_STATICUp0.1973910542
GSE19018Down-0.1494757530
GSE19899_A1Down-0.2207836900
GSE19899_A2Down-0.1330892981
PubMed_21979375_A1Down-0.5499366225
PubMed_21979375_A2Down-0.6730803549
GSE35957Up1.1296211157
GSE36640Down-0.1207011096
GSE54402Up0.0863064265
GSE9593Up0.3365127419
GSE43922Down-0.2205404640
GSE24585Up0.4971358572
GSE37065Down-0.0072228393
GSE28863_A1Up0.0098296870
GSE28863_A2Up0.0217626296
GSE28863_A3Up0.1119065575
GSE28863_A4Down-0.0050257844
GSE48662Down-0.0308325334

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021718MicroarrayFunctional MTI (Weak)17612493
hsa-miR-1226-3pMIMAT0005577MIRT036493CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037733CLASHFunctional MTI (Weak)23622248
hsa-miR-769-3pMIMAT0003887MIRT039096CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039898CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046769CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.