HCSGD entry for EIF2A
1. General information
| Official gene symbol | EIF2A |
|---|---|
| Entrez ID | 83939 |
| Gene full name | eukaryotic translation initiation factor 2A, 65kDa |
| Other gene symbols | EIF-2A MST089 MSTP004 MSTP089 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | IMP | molecular_function |
| GO:0003743 | Translation initiation factor activity | IEA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005850 | Eukaryotic translation initiation factor 2 complex | IDA | cellular_component |
| GO:0006417 | Regulation of translation | IMP | biological_process |
| GO:0006468 | Protein phosphorylation | IEA | biological_process |
| GO:0009967 | Positive regulation of signal transduction | IEA | biological_process |
| GO:0032933 | SREBP signaling pathway | IEA | biological_process |
| GO:0042255 | Ribosome assembly | IMP | biological_process |
| GO:0043022 | Ribosome binding | IMP | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1234887352 | 0.2941446184 | 0.7181266181 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0158271083 |
| GSE13712_SHEAR | Down | -0.1830087425 |
| GSE13712_STATIC | Down | -0.0879219532 |
| GSE19018 | Up | 0.4251759161 |
| GSE19899_A1 | Up | 0.8716085470 |
| GSE19899_A2 | Up | 0.4388711741 |
| PubMed_21979375_A1 | Up | 1.4544086048 |
| PubMed_21979375_A2 | Up | 0.3512123688 |
| GSE35957 | Down | -0.2261232424 |
| GSE36640 | Down | -0.0974199382 |
| GSE54402 | Up | 0.3545792771 |
| GSE9593 | Down | -0.1394934043 |
| GSE43922 | Up | 0.4293283708 |
| GSE24585 | Down | -0.3551372817 |
| GSE37065 | Down | -0.3646743379 |
| GSE28863_A1 | Down | -0.0488643231 |
| GSE28863_A2 | Up | 0.1236516278 |
| GSE28863_A3 | Down | -0.7014823989 |
| GSE28863_A4 | Down | -0.3384310089 |
| GSE48662 | Down | -0.1963648492 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031752 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044991 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT048013 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22788682 | ER stress was detected by assays for glucose-regulated protein 78 (GRP78), CCAAT/enhancer-binding protein homologous protein (CHOP), and growth arrest and DNA damage-inducible protein 34 (GADD34) mRNA, and transient phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha) |
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