HCSGD entry for HDAC10

1. General information

Official gene symbolHDAC10
Entrez ID83933
Gene full namehistone deacetylase 10
Other gene symbolsHD10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000118Histone deacetylase complexIDAcellular_component
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0004407Histone deacetylase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmIDA TAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006476Protein deacetylationIDAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0014003Oligodendrocyte developmentIEAbiological_process
GO:0016568Chromatin modificationNASbiological_process
GO:0016575Histone deacetylationIDAbiological_process
GO:0016787Hydrolase activityIEAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)IEAmolecular_function
GO:0033558Protein deacetylase activityIDAmolecular_function
GO:0042826Histone deacetylase bindingIDAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)IEAmolecular_function
GO:0046970NAD-dependent histone deacetylase activity (H4-K16 specific)IEAmolecular_function
GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific)IEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59933750620.82425841720.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1878958728
GSE13712_SHEARUp0.0720344567
GSE13712_STATICDown-0.1431526583
GSE19018Up0.0973299815
GSE19899_A1Down-0.1362654396
GSE19899_A2Up0.3012060567
PubMed_21979375_A1Up0.2089495026
PubMed_21979375_A2Down-0.0252136058
GSE35957Up0.0427147461
GSE36640Up0.2842786739
GSE54402Up0.0413833502
GSE9593Up0.0154725788
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.0090526195

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PanobinostatDB06603 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-5pMIMAT0000070MIRT050881CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.