HCSGD entry for SPRTN
1. General information
| Official gene symbol | SPRTN |
|---|---|
| Entrez ID | 83932 |
| Gene full name | SprT-like N-terminal domain |
| Other gene symbols | C1orf124 DDDL1880 DVC1 PRO4323 Spartan dJ876B10.3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0009411 | Response to UV | IDA | biological_process |
| GO:0016607 | Nuclear speck | IDA | cellular_component |
| GO:0019985 | Translesion synthesis | IDA IMP | biological_process |
| GO:0031398 | Positive regulation of protein ubiquitination | IDA | biological_process |
| GO:0043130 | Ubiquitin binding | IDA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0070530 | K63-linked polyubiquitin binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0852339349 | 0.5243989780 | 0.6138009302 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0357078272 |
| GSE13712_SHEAR | Up | 0.3700992647 |
| GSE13712_STATIC | Up | 0.7965553311 |
| GSE19018 | Down | -0.7904817737 |
| GSE19899_A1 | Up | 0.2042927287 |
| GSE19899_A2 | Up | 0.1171177754 |
| PubMed_21979375_A1 | Up | 1.4159372204 |
| PubMed_21979375_A2 | Up | 0.4535829496 |
| GSE35957 | Up | 0.5906110205 |
| GSE36640 | Up | 0.2302147279 |
| GSE54402 | Down | -0.0092463225 |
| GSE9593 | Up | 0.1904400901 |
| GSE43922 | Up | 0.1409062342 |
| GSE24585 | Down | -0.2086466294 |
| GSE37065 | Up | 0.1359726844 |
| GSE28863_A1 | Down | -0.3404122085 |
| GSE28863_A2 | Up | 0.2468764900 |
| GSE28863_A3 | Down | -0.3951983583 |
| GSE28863_A4 | Down | -0.0577061017 |
| GSE48662 | Down | -0.2375933299 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-548b-3p | MIMAT0003254 | MIRT016242 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021124 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045716 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045975 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25501849 | Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in translesion synthesis, a DNA damage tolerance process that allows the DNA replication machinery to replicate past nucleotide lesions |
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