HCSGD entry for GSG2
1. General information
| Official gene symbol | GSG2 |
|---|---|
| Entrez ID | 83903 |
| Gene full name | germ cell associated 2 (haspin) |
| Other gene symbols | HASPIN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007064 | Mitotic sister chromatid cohesion | IMP | biological_process |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0071459 | Protein localization to chromosome, centromeric region | IMP | biological_process |
| GO:0072354 | Histone kinase activity (H3-T3 specific) | IMP | molecular_function |
| GO:0090231 | Regulation of spindle checkpoint | IMP | biological_process |
| GO:2000134 | Negative regulation of G1/S transition of mitotic cell cycle | IEA | biological_process |
| GO:2000751 | Histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8217239619 | 0.0226848828 | 0.9999902473 | 0.2898489320 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0226341847 |
| GSE13712_SHEAR | Up | 0.1003905490 |
| GSE13712_STATIC | Down | -0.0794128019 |
| GSE19018 | Down | -0.0598623323 |
| GSE19899_A1 | Up | 0.2521734405 |
| GSE19899_A2 | Down | -1.4293750729 |
| PubMed_21979375_A1 | Down | -0.0420571518 |
| PubMed_21979375_A2 | Down | -1.0528563292 |
| GSE35957 | Down | -0.8851025451 |
| GSE36640 | Down | -2.4350016495 |
| GSE54402 | Down | -0.1599982927 |
| GSE9593 | Down | -0.1004766675 |
| GSE43922 | Down | -0.2179363477 |
| GSE24585 | Down | -0.2389088620 |
| GSE37065 | Down | -0.3900892495 |
| GSE28863_A1 | Down | -0.0165663707 |
| GSE28863_A2 | Up | 0.3868285409 |
| GSE28863_A3 | Up | 0.0319477944 |
| GSE28863_A4 | Up | 0.2985773470 |
| GSE48662 | Down | -0.3991126903 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 5-iodotubercidin | DB04604 | - |
| 3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine | DB07698 | - |
| N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE | DB07995 | - |
| (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol | DB08004 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016277 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016277 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024259 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026264 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036050 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038720 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
