HCSGD entry for TLN2
1. General information
| Official gene symbol | TLN2 |
|---|---|
| Entrez ID | 83660 |
| Gene full name | talin 2 |
| Other gene symbols | ILWEQ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | IEA | cellular_component |
| GO:0003779 | Actin binding | IEA NAS | molecular_function |
| GO:0005158 | Insulin receptor binding | IEA | molecular_function |
| GO:0005198 | Structural molecule activity | IEA NAS | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005911 | Cell-cell junction | IC | cellular_component |
| GO:0005916 | Fascia adherens | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IEA | cellular_component |
| GO:0007016 | Cytoskeletal anchoring at plasma membrane | IEA | biological_process |
| GO:0007043 | Cell-cell junction assembly | TAS | biological_process |
| GO:0007155 | Cell adhesion | IEA NAS | biological_process |
| GO:0015629 | Actin cytoskeleton | IEA NAS | cellular_component |
| GO:0045202 | Synapse | NAS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1400722427 | 0.4645874131 | 0.7524138487 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0276389097 |
| GSE13712_SHEAR | Down | -0.0931969147 |
| GSE13712_STATIC | Down | -0.1563923492 |
| GSE19018 | Down | -0.1942016165 |
| GSE19899_A1 | Up | 0.0471027189 |
| GSE19899_A2 | Down | -0.2781723048 |
| PubMed_21979375_A1 | Up | 0.1861290687 |
| PubMed_21979375_A2 | Up | 0.3950179819 |
| GSE35957 | Down | -0.2998854924 |
| GSE36640 | Down | -0.1239463128 |
| GSE54402 | Down | -0.1752844676 |
| GSE9593 | Down | -0.0221611854 |
| GSE43922 | Up | 0.2496709640 |
| GSE24585 | Up | 0.4006352205 |
| GSE37065 | Down | -0.5274518002 |
| GSE28863_A1 | Up | 1.3788236410 |
| GSE28863_A2 | Up | 1.0595663430 |
| GSE28863_A3 | Down | -0.1262039411 |
| GSE28863_A4 | Up | 0.0419773766 |
| GSE48662 | Down | -0.2340778888 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-194-5p | MIMAT0000460 | MIRT006999 | Luciferase reporter assay | Functional MTI | 22829924 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT007253 | Luciferase reporter assay | Functional MTI | 22310291 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT007253 | Luciferase reporter assay | Functional MTI | 22330136 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
