HCSGD entry for HIST1H4A
1. General information
| Official gene symbol | HIST1H4A |
|---|---|
| Entrez ID | 8359 |
| Gene full name | histone cluster 1, H4a |
| Other gene symbols | H4FA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000723 | Telomere maintenance | TAS | biological_process |
| GO:0000786 | Nucleosome | TAS | cellular_component |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006325 | Chromatin organization | NAS | biological_process |
| GO:0006334 | Nucleosome assembly | TAS | biological_process |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0034080 | CENP-A containing nucleosome assembly at centromere | TAS | biological_process |
| GO:0045653 | Negative regulation of megakaryocyte differentiation | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0048015 | Phosphatidylinositol-mediated signaling | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8621443676 | 0.0582831465 | 0.9999902473 | 0.4540013909 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0796869275 |
| GSE13712_SHEAR | Down | -0.0141030770 |
| GSE13712_STATIC | Up | 0.0241377829 |
| GSE19018 | Up | 0.2167752402 |
| GSE19899_A1 | Up | 0.1096410062 |
| GSE19899_A2 | Down | -0.1215915159 |
| PubMed_21979375_A1 | Up | 0.1094288766 |
| PubMed_21979375_A2 | Down | -0.2921336047 |
| GSE35957 | Up | 0.0349413824 |
| GSE36640 | Down | -0.4734258673 |
| GSE54402 | Up | 0.0580843410 |
| GSE9593 | Down | -0.0834521569 |
| GSE43922 | Down | -0.2893946837 |
| GSE24585 | Down | -0.4517856137 |
| GSE37065 | Down | -0.1618877187 |
| GSE28863_A1 | Down | -0.6469348897 |
| GSE28863_A2 | Up | 0.3149161665 |
| GSE28863_A3 | Down | -1.0491226963 |
| GSE28863_A4 | Down | -0.0142457435 |
| GSE48662 | Up | 0.3313842031 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025252 | Proteomics | Functional MTI (Weak) | 21566225 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 18056640 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
