HCSGD entry for NUF2


1. General information

Official gene symbolNUF2
Entrez ID83540
Gene full nameNUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Other gene symbolsCDCA1 CT106 NUF2R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0000775Chromosome, centromeric regionIEA NAScellular_component
GO:0000777Condensed chromosome kinetochoreIEAcellular_component
GO:0003674Molecular_functionNDmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0007059Chromosome segregationNASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0031262Ndc80 complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88782477110.00000646250.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-2.8307230733
GSE13712_SHEARDown-0.2361152748
GSE13712_STATICDown-0.7148891008
GSE19018Up0.4495010060
GSE19899_A1Down-2.1603484964
GSE19899_A2Down-5.3012933799
PubMed_21979375_A1Down-5.0470317185
PubMed_21979375_A2Down-7.1267339806
GSE35957Down-5.0536018599
GSE36640Down-6.1052630689
GSE54402Down-1.4487294852
GSE9593Down-2.4602898713
GSE43922Down-2.7736590186
GSE24585Up0.0581122930
GSE37065Down-0.4226414989
GSE28863_A1Down-0.1475539352
GSE28863_A2Up1.0393995114
GSE28863_A3Up0.1053644104
GSE28863_A4Up0.0916338593
GSE48662Down-2.4296963535

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024606MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026247MicroarrayFunctional MTI (Weak)19074876
hsa-miR-221-3pMIMAT0000278MIRT046921CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26572216In total, 10 gene modules associated with cell senescence were detected, and six hub genes were identified, including Bcell scaffold protein with ankyrin repeats 1, translocase of outer mitochondrial membrane 70 homolog A, actin filamentassociated protein 1, Cd84, Nuf2 and nuclear factor erythroid 2
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