HCSGD entry for HIST2H2BE
1. General information
| Official gene symbol | HIST2H2BE |
|---|---|
| Entrez ID | 8349 |
| Gene full name | histone cluster 2, H2be |
| Other gene symbols | GL105 H2B H2B.1 H2BFQ H2BGL105 H2BQ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000786 | Nucleosome | NAS | cellular_component |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006334 | Nucleosome assembly | NAS | biological_process |
| GO:0042742 | Defense response to bacterium | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000107329 | 0.9841347213 | 0.0115777778 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.6129398352 |
| GSE13712_SHEAR | Up | 1.6799306570 |
| GSE13712_STATIC | Up | 1.2418853171 |
| GSE19018 | Up | 0.5873065334 |
| GSE19899_A1 | Up | 2.3843301939 |
| GSE19899_A2 | Up | 3.3042542425 |
| PubMed_21979375_A1 | Up | 1.5431624954 |
| PubMed_21979375_A2 | Up | 3.1030880885 |
| GSE35957 | Up | 1.4104092324 |
| GSE36640 | Up | 4.9198140950 |
| GSE54402 | Up | 0.8664215045 |
| GSE9593 | Up | 0.6553436499 |
| GSE43922 | Up | 0.4134830776 |
| GSE24585 | Up | 1.2859659962 |
| GSE37065 | Up | 0.9431781479 |
| GSE28863_A1 | Up | 0.2283899391 |
| GSE28863_A2 | Up | 0.3898145624 |
| GSE28863_A3 | Up | 0.3636319799 |
| GSE28863_A4 | Down | -1.0443568625 |
| GSE48662 | Up | 0.1126146365 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025415 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027073 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031573 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037085 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038016 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038396 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040129 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052380 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24025678 | Moreover, deficiencies in the H2B ubiquitylase complex Rad6/Bre1 as well as the deubiquitylase Ubp10 reduced the lifespan by altering both H3K4 and H3K79 methylation and Sir2 recruitment |
| 24025678 | Thus, these results show that low levels of H2B ubiquitylation are a prerequisite for a normal lifespan and the trans-tail regulation of histone modifications regulates age-associated Sir2 recruitment through telomeric silencing |
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