HCSGD entry for CARS
1. General information
| Official gene symbol | CARS |
|---|---|
| Entrez ID | 833 |
| Gene full name | cysteinyl-tRNA synthetase |
| Other gene symbols | CARS1 CYSRS MGC:11246 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | IDA IMP NAS | molecular_function |
| GO:0004817 | Cysteine-tRNA ligase activity | IDA IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA NAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006423 | Cysteinyl-tRNA aminoacylation | IDA IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA IMP | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0136168687 | 0.9792831313 | 0.2910184253 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0057502154 |
| GSE13712_SHEAR | Up | 0.3320310101 |
| GSE13712_STATIC | Up | 0.0027310145 |
| GSE19018 | Up | 0.7212672323 |
| GSE19899_A1 | Up | 0.4310526157 |
| GSE19899_A2 | Up | 0.5418908136 |
| PubMed_21979375_A1 | Up | 0.7411045328 |
| PubMed_21979375_A2 | Down | -0.1891791869 |
| GSE35957 | Down | -0.2215294640 |
| GSE36640 | Up | 0.2845842512 |
| GSE54402 | Up | 0.1614559779 |
| GSE9593 | Up | 0.5047575169 |
| GSE43922 | Up | 0.5526086736 |
| GSE24585 | Up | 0.0606240809 |
| GSE37065 | Down | -0.3854263523 |
| GSE28863_A1 | Up | 0.5846216600 |
| GSE28863_A2 | Up | 0.2170916808 |
| GSE28863_A3 | Up | 0.2237505748 |
| GSE28863_A4 | Up | 0.0559659020 |
| GSE48662 | Up | 0.3315791785 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Cysteine | DB00151 | NUTR00018 | DB04443 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020880 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039547 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049593 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT049940 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
