HCSGD entry for AXIN1

1. General information

Official gene symbolAXIN1
Entrez ID8312
Gene full nameaxin 1
Other gene symbolsAXIN PPP1R49
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000209Protein polyubiquitinationIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001743Optic placode formationIBAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0004871Signal transducer activityIDA IEAmolecular_function
GO:0005096GTPase activator activityIBAmolecular_function
GO:0005102Receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005881Cytoplasmic microtubuleIBAcellular_component
GO:0005938Cell cortexIBAcellular_component
GO:0006913Nucleocytoplasmic transportIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007257Activation of JUN kinase activityIBAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007368Determination of left/right symmetryIBAbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0008013Beta-catenin bindingIDAmolecular_function
GO:0008022Protein C-terminus bindingIEAmolecular_function
GO:0008219Cell deathIBAbiological_process
GO:0009950Dorsal/ventral axis specificationIBAbiological_process
GO:0010800Positive regulation of peptidyl-threonine phosphorylationNASbiological_process
GO:0014069Postsynaptic densityIBAcellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIBAcellular_component
GO:0016328Lateral plasma membraneIDAcellular_component
GO:0019899Enzyme bindingIPImolecular_function
GO:0019901Protein kinase bindingIBA ISSmolecular_function
GO:0021797Forebrain anterior/posterior pattern specificationIBAbiological_process
GO:0021881Wnt-activated signaling pathway involved in forebrain neuron fate commitmentIBAbiological_process
GO:0030163Protein catabolic processIEAbiological_process
GO:0030178Negative regulation of Wnt signaling pathwayIDAbiological_process
GO:0030511Positive regulation of transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0030877Beta-catenin destruction complexIDAcellular_component
GO:0030910Olfactory placode formationIBAbiological_process
GO:0031122Cytoplasmic microtubule organizationIBAbiological_process
GO:0031398Positive regulation of protein ubiquitinationNASbiological_process
GO:0031410Cytoplasmic vesicleISScellular_component
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032147Activation of protein kinase activityIDAbiological_process
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0032947Protein complex scaffoldIDA IMPmolecular_function
GO:0033138Positive regulation of peptidyl-serine phosphorylationNASbiological_process
GO:0034244Negative regulation of transcription elongation from RNA polymerase II promoterIEAbiological_process
GO:0035412Regulation of catenin import into nucleusIBAbiological_process
GO:0036342Post-anal tail morphogenesisIEAbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0042802Identical protein bindingISSmolecular_function
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043547Positive regulation of GTPase activityIBAbiological_process
GO:0043621Protein self-associationIEAmolecular_function
GO:0043623Cellular protein complex assemblyIDAbiological_process
GO:0045599Negative regulation of fat cell differentiationIBAbiological_process
GO:0045732Positive regulation of protein catabolic processIC IDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0046330Positive regulation of JNK cascadeISSbiological_process
GO:0046332SMAD bindingIPImolecular_function
GO:0048048Embryonic eye morphogenesisIBAbiological_process
GO:0048320Axial mesoderm formationIBAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051248Negative regulation of protein metabolic processIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051443Positive regulation of ubiquitin-protein ligase activityIMPbiological_process
GO:0055001Muscle cell developmentIBAbiological_process
GO:0060070Canonical Wnt signaling pathwayICbiological_process
GO:0060272Embryonic skeletal joint morphogenesisIBAbiological_process
GO:0060823Canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formationIBAbiological_process
GO:0070016Armadillo repeat domain bindingIBA ISSmolecular_function
GO:0070411I-SMAD bindingIPImolecular_function
GO:0070412R-SMAD bindingIEAmolecular_function
GO:0071407Cellular response to organic cyclic compoundIBAbiological_process
GO:0071514Genetic imprintingIEAbiological_process
GO:0071944Cell peripheryIDAcellular_component
GO:0090090Negative regulation of canonical Wnt signaling pathwayIBAbiological_process
GO:0090244Wnt signaling pathway involved in somitogenesisIBAbiological_process
GO:2000060Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16251922040.85390546330.79747733041.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1096285809
GSE13712_SHEARUp0.1019805951
GSE13712_STATICUp0.0501579383
GSE19018Down-0.0124767306
GSE19899_A1Up0.0858647177
GSE19899_A2Up0.7873763429
PubMed_21979375_A1Up0.4528095254
PubMed_21979375_A2Up0.4715286111
GSE35957Down-0.0502697411
GSE36640Down-0.0848820281
GSE54402Up0.4897334423
GSE9593Up0.1358387877
GSE43922Up0.0907869236
GSE24585Down-0.2477347691
GSE37065Down-0.1236022742
GSE28863_A1Down-0.0719792078
GSE28863_A2Down-0.0016518753
GSE28863_A3Up0.0780973116
GSE28863_A4Down-0.0521710976
GSE48662Up0.4974023500

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

1,4-DithiothreitolDB04447 EXPT01291

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018487MicroarrayFunctional MTI (Weak)18185580
hsa-miR-320cMIMAT0005793MIRT036160CLASHFunctional MTI (Weak)23622248
hsa-miR-769-3pMIMAT0003887MIRT039102CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041736CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044503CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049195CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.