HCSGD entry for PICALM
1. General information
| Official gene symbol | PICALM |
|---|---|
| Entrez ID | 8301 |
| Gene full name | phosphatidylinositol binding clathrin assembly protein |
| Other gene symbols | CALM CLTH LAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005543 | Phospholipid binding | IEA | molecular_function |
| GO:0005545 | 1-phosphatidylinositol binding | IEA ISS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005905 | Coated pit | IDA ISS | cellular_component |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0006898 | Receptor-mediated endocytosis | IDA ISS | biological_process |
| GO:0007409 | Axonogenesis | IEA | biological_process |
| GO:0016192 | Vesicle-mediated transport | TAS | biological_process |
| GO:0016197 | Endosomal transport | IMP | biological_process |
| GO:0030097 | Hemopoiesis | IEA | biological_process |
| GO:0030100 | Regulation of endocytosis | IMP | biological_process |
| GO:0030118 | Clathrin coat | IEA | cellular_component |
| GO:0030122 | AP-2 adaptor complex | IDA | cellular_component |
| GO:0030132 | Clathrin coat of coated pit | IDA | cellular_component |
| GO:0030276 | Clathrin binding | IDA IEA ISS | molecular_function |
| GO:0031623 | Receptor internalization | IMP | biological_process |
| GO:0032050 | Clathrin heavy chain binding | IDA | molecular_function |
| GO:0032880 | Regulation of protein localization | IDA | biological_process |
| GO:0042734 | Presynaptic membrane | ISS | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045211 | Postsynaptic membrane | ISS | cellular_component |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0048261 | Negative regulation of receptor-mediated endocytosis | IDA | biological_process |
| GO:0048268 | Clathrin coat assembly | IEA IMP | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA ISS | cellular_component |
| GO:0048813 | Dendrite morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9302692641 | 0.0603703659 | 0.9999902473 | 0.4628629187 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4193387075 |
| GSE13712_SHEAR | Up | 0.0171588465 |
| GSE13712_STATIC | Down | -0.1757255274 |
| GSE19018 | Down | -0.2440963907 |
| GSE19899_A1 | Down | -0.6876262598 |
| GSE19899_A2 | Down | -0.0366174398 |
| PubMed_21979375_A1 | Down | -0.4682331776 |
| PubMed_21979375_A2 | Down | -1.0911218296 |
| GSE35957 | Up | 0.3467857396 |
| GSE36640 | Up | 0.1176488567 |
| GSE54402 | Up | 0.0681610902 |
| GSE9593 | Up | 0.1966579127 |
| GSE43922 | Down | -0.1114061437 |
| GSE24585 | Up | 0.0635185521 |
| GSE37065 | Up | 0.1438045891 |
| GSE28863_A1 | Down | -0.1829319606 |
| GSE28863_A2 | Down | -0.0110554457 |
| GSE28863_A3 | Down | -0.6342301544 |
| GSE28863_A4 | Up | 0.0762957473 |
| GSE48662 | Down | -0.0400323730 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001350 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT001350 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001525 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001525 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023209 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027784 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028681 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
