HCSGD entry for CAPN2
1. General information
| Official gene symbol | CAPN2 |
|---|---|
| Entrez ID | 824 |
| Gene full name | calpain 2, (m/II) large subunit |
| Other gene symbols | CANP2 CANPL2 CANPml mCANP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000785 | Chromatin | IEA | cellular_component |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0001824 | Blastocyst development | IEA | biological_process |
| GO:0004198 | Calcium-dependent cysteine-type endopeptidase activity | IEA ISS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA ISS | biological_process |
| GO:0007520 | Myoblast fusion | IEA | biological_process |
| GO:0008092 | Cytoskeletal protein binding | IEA | molecular_function |
| GO:0008234 | Cysteine-type peptidase activity | TAS | molecular_function |
| GO:0016540 | Protein autoprocessing | IEA | biological_process |
| GO:0030425 | Dendrite | ISS | cellular_component |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0071230 | Cellular response to amino acid stimulus | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5717043197 | 0.3927568253 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0952379226 |
| GSE13712_SHEAR | Down | -0.0557427285 |
| GSE13712_STATIC | Down | -0.0492201173 |
| GSE19018 | Up | 0.0308114418 |
| GSE19899_A1 | Up | 0.0909199771 |
| GSE19899_A2 | Down | -0.0804210359 |
| PubMed_21979375_A1 | Down | -0.0948154990 |
| PubMed_21979375_A2 | Down | -0.1590497230 |
| GSE35957 | Down | -0.0833206667 |
| GSE36640 | Down | -0.1939820680 |
| GSE54402 | Up | 0.0418585962 |
| GSE9593 | Up | 0.1904420761 |
| GSE43922 | Up | 0.0503582971 |
| GSE24585 | Up | 0.7016962561 |
| GSE37065 | Down | -0.0732631355 |
| GSE28863_A1 | Down | -0.0287003121 |
| GSE28863_A2 | Up | 0.3942543267 |
| GSE28863_A3 | Down | -0.5236144682 |
| GSE28863_A4 | Down | -0.1301468081 |
| GSE48662 | Down | -0.7184166213 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025966 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027353 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028659 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24838245 | Based on relative mRNA levels, Capn5 is the second most highly expressed calpain in the rat CNS, with Capn2 mRNA being the most abundant |
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