HCSGD entry for CAPG
1. General information
| Official gene symbol | CAPG |
|---|---|
| Entrez ID | 822 |
| Gene full name | capping protein (actin filament), gelsolin-like |
| Other gene symbols | AFCP MCP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006461 | Protein complex assembly | NAS | biological_process |
| GO:0008290 | F-actin capping protein complex | TAS | cellular_component |
| GO:0030031 | Cell projection assembly | IEA | biological_process |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0051016 | Barbed-end actin filament capping | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9057216101 | 0.0052708978 | 0.9999902473 | 0.1479054371 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2832767051 |
| GSE13712_SHEAR | Up | 0.1427671030 |
| GSE13712_STATIC | Up | 0.1113360269 |
| GSE19018 | Up | 0.2555146089 |
| GSE19899_A1 | Down | -0.8061232284 |
| GSE19899_A2 | Down | -1.1108946617 |
| PubMed_21979375_A1 | Down | -0.0866531769 |
| PubMed_21979375_A2 | Down | -1.0262352495 |
| GSE35957 | Down | -0.9947110130 |
| GSE36640 | Down | -0.6982443909 |
| GSE54402 | Down | -0.5930016246 |
| GSE9593 | Up | 0.3260105004 |
| GSE43922 | Down | -0.2246322742 |
| GSE24585 | Up | 0.4507918484 |
| GSE37065 | Down | -0.1533462866 |
| GSE28863_A1 | Down | -0.6386348218 |
| GSE28863_A2 | Down | -0.2481490168 |
| GSE28863_A3 | Down | -0.6045098263 |
| GSE28863_A4 | Down | -0.0176197359 |
| GSE48662 | Down | -0.2212151388 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001646 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023906 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025493 | Proteomics | Functional MTI (Weak) | 21566225 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19925638 | Identified proteins could be classified into several functional categories: (i) cytoskeletal regulators: CapG and cofilin 1; (ii) stress response and signal pathway proteins: TXNDC5 and RSU-1; and (iii) apoptosis proteins: Annexin V |
| 19925638 | We confirmed by Western blot a decrease of RSU-1, CapG and TXNDC5 in PBMCs from old donors |
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