HCSGD entry for NCOA3
1. General information
| Official gene symbol | NCOA3 |
|---|---|
| Entrez ID | 8202 |
| Gene full name | nuclear receptor coactivator 3 |
| Other gene symbols | ACTR AIB-1 AIB1 CAGH16 CTG26 KAT13B RAC3 SRC-3 SRC3 TNRC14 TNRC16 TRAM-1 bHLHe42 pCIP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA IEA IMP NAS | molecular_function |
| GO:0004402 | Histone acetyltransferase activity | IDA IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IMP | biological_process |
| GO:0016573 | Histone acetylation | IDA | biological_process |
| GO:0016922 | Ligand-dependent nuclear receptor binding | IPI | molecular_function |
| GO:0030521 | Androgen receptor signaling pathway | NAS | biological_process |
| GO:0035257 | Nuclear hormone receptor binding | IDA IEA | molecular_function |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0035624 | Receptor transactivation | TAS | biological_process |
| GO:0045618 | Positive regulation of keratinocyte differentiation | IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IMP | biological_process |
| GO:0046966 | Thyroid hormone receptor binding | NAS | molecular_function |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0048589 | Developmental growth | IEA | biological_process |
| GO:0050681 | Androgen receptor binding | NAS | molecular_function |
| GO:0060068 | Vagina development | IEA | biological_process |
| GO:0060713 | Labyrinthine layer morphogenesis | IEA | biological_process |
| GO:0060744 | Mammary gland branching involved in thelarche | IEA | biological_process |
| GO:2001141 | Regulation of RNA biosynthetic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0190282778 | 0.9720790851 | 0.3364691275 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1429913358 |
| GSE13712_SHEAR | Up | 0.2942283176 |
| GSE13712_STATIC | Up | 0.0360281916 |
| GSE19018 | Up | 0.0014432752 |
| GSE19899_A1 | Up | 0.2176420568 |
| GSE19899_A2 | Up | 0.3887671608 |
| PubMed_21979375_A1 | Down | -0.2040894965 |
| PubMed_21979375_A2 | Up | 0.4702253659 |
| GSE35957 | Up | 0.5462818087 |
| GSE36640 | Up | 0.7000561494 |
| GSE54402 | Up | 0.3677040827 |
| GSE9593 | Up | 0.9766041726 |
| GSE43922 | Up | 0.2737604996 |
| GSE24585 | Up | 0.6398137892 |
| GSE37065 | Up | 0.0411095450 |
| GSE28863_A1 | Up | 0.0200654707 |
| GSE28863_A2 | Up | 0.2099879222 |
| GSE28863_A3 | Down | -0.5492065528 |
| GSE28863_A4 | Up | 0.1652774930 |
| GSE48662 | Up | 0.1814611043 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT004305 | Luciferase reporter assay | Non-Functional MTI | 19528081 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT004305 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT004306 | Luciferase reporter assay | Non-Functional MTI | 19528081 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT004310 | Western blot | Non-Functional MTI | 19706389 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT004311 | Western blot | Non-Functional MTI | 19706389 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT004312 | Western blot | Functional MTI | 19706389 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT005408 | Luciferase reporter assay//Northern blot//qRT-PCR//Western blot//Northern blot;Western blot;qRT-PCR | Functional MTI | 16940181 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT007358 | Immunofluorescence//Luciferase reporter assay//Western blot | Functional MTI | 23547260 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016187 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018366 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024566 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026651 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037458 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050588 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26469953 | RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging |
| 26469953 | Receptor-associated coactivator 3 (RAC3) is a nuclear receptor coactivator usually overexpressed in tumors that exerts oncogenic functions in the cytoplasm and the nucleus |
| 26469953 | We found that RAC3 overexpression in the nontumoral HEK293 cells inhibits the premature senescence induced by hydrogen peroxide or rapamycin |
| 26469953 | Furthermore, we found that RAC3 overexpression is required in order to maintain the telomerase activity |
| 26469953 | In tumoral HeLa cells its activity was inhibited by depletion of RAC3 inducing replicative senescence |
| 26469953 | Moreover, we demonstrated that in vivo, levels of RAC3 are downregulated in the liver from aged as compared with young rats, whereas the levels of p21 are increased, correlating with the expected senescent cell contents in aged tissues |
| 26469953 | A similar downregulation of RAC3 was observed in the premature and replicative senescence of human fetal WI-38 cells and premature senescence of hepatocyte HepG2 cell line |
| 26469953 | Taken together, all these results demonstrate that RAC3 is an inhibitor of senescence whose downregulation in aged individuals could be probably a tumor suppressor mechanism, avoiding the clonal expansion of risky old cells having damaged DNA |
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