HCSGD entry for CLPP
1. General information
| Official gene symbol | CLPP |
|---|---|
| Entrez ID | 8192 |
| Gene full name | ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008233 | Peptidase activity | TAS | molecular_function |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0051260 | Protein homooligomerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9376958512 | 0.0648339235 | 0.9999902473 | 0.4807024507 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0423160557 |
| GSE13712_SHEAR | Down | -0.1153341510 |
| GSE13712_STATIC | Down | -0.1653776929 |
| GSE19018 | Up | 0.3176326524 |
| GSE19899_A1 | Up | 0.0417476807 |
| GSE19899_A2 | Up | 0.3905216045 |
| PubMed_21979375_A1 | Up | 0.7908200967 |
| PubMed_21979375_A2 | Down | -0.1741602594 |
| GSE35957 | Down | -0.3825865840 |
| GSE36640 | Down | -0.3989362747 |
| GSE54402 | Down | -0.0271239623 |
| GSE9593 | Down | -0.4376257835 |
| GSE43922 | Down | -0.0152779760 |
| GSE24585 | Down | -0.4097552590 |
| GSE37065 | Down | -0.1461450523 |
| GSE28863_A1 | Down | -0.5722087290 |
| GSE28863_A2 | Down | -0.3231179794 |
| GSE28863_A3 | Down | -0.0572793307 |
| GSE28863_A4 | Down | -0.0062661761 |
| GSE48662 | Down | -0.1571463789 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| N-Formylmethionine | DB04464 | EXPT01455 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-128-3p | MIMAT0000424 | MIRT022076 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039835 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17403784 | The data further suggest that sigma(S) becomes stabilized upon starvation as a result of ClpP sequestration and this sequestration is enhanced by oxidative modifications of aberrant proteins produced by erroneous translation |
| 17403784 | ClpP overproduction counteracted starvation-induced stabilization of sigma(S), whereas overproduction of a ClpXP substrate (ssrA-tagged GFP) stabilized sigma(S) in exponentially growing cells |
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