HCSGD entry for SHARPIN

1. General information

Official gene symbolSHARPIN
Entrez ID81858
Gene full nameSHANK-associated RH domain interactor
Other gene symbolsSIPL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolIDAcellular_component
GO:0007005Mitochondrion organizationIEAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010803Regulation of tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0030262Apoptotic nuclear changesIEAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0031424KeratinizationIEAbiological_process
GO:0031593Polyubiquitin bindingIDAmolecular_function
GO:0032403Protein complex bindingIEAmolecular_function
GO:0042802Identical protein bindingIEAmolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0050728Negative regulation of inflammatory responseIEA ISSbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0071797LUBAC complexIDA IEAcellular_component
GO:0097039Protein linear polyubiquitinationIDAbiological_process
GO:2000348Regulation of CD40 signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30523560280.71499164930.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2316230078
GSE13712_SHEARDown-0.2806477101
GSE13712_STATICUp0.1577327861
GSE19018Down-0.0304285690
GSE19899_A1Down-0.3694130329
GSE19899_A2Up0.5531922549
PubMed_21979375_A1Up0.2258105276
PubMed_21979375_A2Up0.1283040934
GSE35957Down-0.1033177963
GSE36640Up0.5784362667
GSE54402Down-0.0081264266
GSE9593Up0.3956491095
GSE43922Up0.0432370952
GSE24585Up0.2779026217
GSE37065Down-0.1803634550
GSE28863_A1Down-0.2503229762
GSE28863_A2Down-0.0784695607
GSE28863_A3Down-0.0540400795
GSE28863_A4Down-0.0191064820
GSE48662Up0.2596717004

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.