HCSGD entry for CDT1
1. General information
| Official gene symbol | CDT1 |
|---|---|
| Entrez ID | 81620 |
| Gene full name | chromatin licensing and DNA replication factor 1 |
| Other gene symbols | DUP RIS2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000076 | DNA replication checkpoint | IDA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000083 | Regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003677 | DNA binding | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0030174 | Regulation of DNA-dependent DNA replication initiation | IDA | biological_process |
| GO:0033262 | Regulation of nuclear cell cycle DNA replication | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9518623267 | 0.0016173018 | 0.9999902473 | 0.0775391621 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1559333006 |
| GSE13712_SHEAR | Down | -0.2256020068 |
| GSE13712_STATIC | Down | -0.4445731230 |
| GSE19018 | Down | -0.1257998938 |
| GSE19899_A1 | Down | -0.7016809834 |
| GSE19899_A2 | Down | -1.9589444959 |
| PubMed_21979375_A1 | Down | -1.3181992815 |
| PubMed_21979375_A2 | Down | -3.0155131480 |
| GSE35957 | Down | -1.3178346900 |
| GSE36640 | Down | -2.4588241656 |
| GSE54402 | Down | -0.2328361412 |
| GSE9593 | Down | -1.0665352021 |
| GSE43922 | Up | 0.0353285522 |
| GSE24585 | Up | 0.1774556887 |
| GSE37065 | Down | -0.1011497825 |
| GSE28863_A1 | Down | -0.1715294539 |
| GSE28863_A2 | Up | 0.1772998014 |
| GSE28863_A3 | Up | 0.4259343591 |
| GSE28863_A4 | Up | 0.1355346036 |
| GSE48662 | Down | -1.7987329287 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016534 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045201 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050529 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23142824 | Cdt1 is a central regulator of DNA replication licensing acting during the G1 phase and it is negatively controlled by Geminin |
| 23142824 | Here, we characterize the cell cycle expression pattern of Cdt1 and Geminin during successive passages of primary fibroblasts and compare it to tumour-derived cell lines |
| 23142824 | Cdt1 and Geminin are strictly expressed in distinct subpopulations of young fibroblasts, similarly to cancer cells, with Geminin accumulating shortly after the onset of S phase |
| 23142824 | Cdt1 and Geminin are down-regulated when primary human and mouse fibroblasts undergo replicative or stress-induced senescence |
| 21159650 | NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells |
| 21159650 | Here we show that stabilization of the DNA replication factor Cdt1, a substrate of cullins 1 and 4, is critical for MLN4924 to trigger DNA rereplication and inhibit cell proliferation |
| 21159650 | Even only 1 hour of exposure to MLN4924, which was sufficient to elevate Cdt1 for 4-5 hours, was found to be sufficient to induce DNA rereplication and to activate apoptosis and senescence pathways |
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