HCSGD entry for TXNDC5
1. General information
| Official gene symbol | TXNDC5 |
|---|---|
| Entrez ID | 81567 |
| Gene full name | thioredoxin domain containing 5 (endoplasmic reticulum) |
| Other gene symbols | ENDOPDI ERP46 HCC-2 PDIA15 STRF8 UNQ364 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | TAS | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | IEA | cellular_component |
| GO:0006662 | Glycerol ether metabolic process | IEA | biological_process |
| GO:0006892 | Post-Golgi vesicle-mediated transport | TAS | biological_process |
| GO:0015035 | Protein disulfide oxidoreductase activity | IEA | molecular_function |
| GO:0016853 | Isomerase activity | IEA | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9979085673 | 0.0655134797 | 0.9999902473 | 0.4832904428 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.3033990514 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-505-5p | MIMAT0004776 | MIRT037960 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042668 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT049868 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25526565 | TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology |
| 25526565 | Thioredoxin domain-containing 5 (TXNDC5) is a member of the protein disulfide isomerase family, acting as a chaperone of endoplasmic reticulum under not fully characterized conditions As a result, TXNDC5 interacts with many cell proteins, contributing to their proper folding and correct formation of disulfide bonds through its thioredoxin domains |
| 25526565 | As can be inferred from all these functions, TXNDC5 plays an important role in cell physiology; therefore, dysregulation of its expression is associated with oxidative stress, cell ageing and a large range of pathologies such as arthritis, cancer, diabetes, neurodegenerative diseases, vitiligo and virus infections |
| 25526565 | Its implication in all these important diseases has made TXNDC5 a susceptible biomarker or even a potential pharmacological target |
| 19925638 | Identified proteins could be classified into several functional categories: (i) cytoskeletal regulators: CapG and cofilin 1; (ii) stress response and signal pathway proteins: TXNDC5 and RSU-1; and (iii) apoptosis proteins: Annexin V |
| 19925638 | We confirmed by Western blot a decrease of RSU-1, CapG and TXNDC5 in PBMCs from old donors |
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