HCSGD entry for PABPN1
1. General information
| Official gene symbol | PABPN1 |
|---|---|
| Entrez ID | 8106 |
| Gene full name | poly(A) binding protein, nuclear 1 |
| Other gene symbols | OPMD PAB2 PABII PABP-2 PABP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006369 | Termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016973 | Poly(A)+ mRNA export from nucleus | IMP | biological_process |
| GO:0019048 | Modulation by virus of host morphology or physiology | TAS | biological_process |
| GO:0019054 | Modulation by virus of host process | TAS | biological_process |
| GO:0019058 | Viral life cycle | TAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0031124 | MRNA 3'-end processing | TAS | biological_process |
| GO:0046778 | Modification by virus of host mRNA processing | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4215139508 | 0.2326337867 | 0.9999902473 | 0.9291584067 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0970960830 |
| GSE13712_SHEAR | Up | 0.0545514364 |
| GSE13712_STATIC | Down | -0.6311573739 |
| GSE19018 | Up | 0.0272179258 |
| GSE19899_A1 | Down | -0.1350895762 |
| GSE19899_A2 | Up | 0.5529632013 |
| PubMed_21979375_A1 | Down | -0.5094151623 |
| PubMed_21979375_A2 | Up | 0.2339236937 |
| GSE35957 | Down | -0.5798319181 |
| GSE36640 | Up | 0.7307716900 |
| GSE54402 | Down | -0.0961492750 |
| GSE9593 | Down | -0.6288691546 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0609802917 |
| GSE28863_A2 | Down | -0.0690682315 |
| GSE28863_A3 | Down | -0.0250552912 |
| GSE28863_A4 | Up | 0.3002172264 |
| GSE48662 | Down | -0.2287980728 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT040418 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040712 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049653 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23793615 | A decline in PABPN1 induces progressive muscle weakness in oculopharyngeal muscle dystrophy and in muscle aging |
| 23793615 | Oculopharyngeal muscular dystrophy (OPMD) is caused by trinucleotide repeat expansion mutations in Poly(A) binding protein 1 (PABPN1) |
| 23793615 | PABPN1 is a regulator of mRNA stability and is ubiquitously expressed |
| 23793615 | Here we investigated how symptoms in OPMD initiate only at midlife and why a subset of skeletal muscles is predominantly affected |
| 23793615 | Major expression changes were found to be associated with age rather than with expression of expanded-PABPN1, instead transcriptomes of OPMD and elderly muscles were significantly similar (P<0 |
| 23793615 | Using k-means clustering we identified age-dependent trends in both OPMD and controls, but trends were often accelerated in OPMD |
| 23793615 | We report an age-regulated decline in PABPN1 levels in Vastus lateralis muscles from the fifth decade |
| 23793615 | In concurrence with severe muscle degeneration in OPMD, the decline in PABPN1 accelerated in OPMD and was specific to skeletal muscles |
| 23793615 | Reduced PABPN1 levels (30% to 60%) in muscle cells induced myogenic defects and morphological signatures of cellular aging in proportion to PABPN1 expression levels |
| 23793615 | We suggest that PABPN1 levels regulate muscle cell aging and OPMD represents an accelerated muscle aging disorder |
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