HCSGD entry for ACTN4
1. General information
| Official gene symbol | ACTN4 |
|---|---|
| Entrez ID | 81 |
| Gene full name | actinin, alpha 4 |
| Other gene symbols | ACTININ-4 FSGS FSGS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0001725 | Stress fiber | IEA | cellular_component |
| GO:0001882 | Nucleoside binding | IDA | molecular_function |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0003779 | Actin binding | IEA TAS | molecular_function |
| GO:0005178 | Integrin binding | TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005911 | Cell-cell junction | IEA | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0030863 | Cortical cytoskeleton | IEA | cellular_component |
| GO:0031093 | Platelet alpha granule lumen | TAS | cellular_component |
| GO:0031143 | Pseudopodium | TAS | cellular_component |
| GO:0032417 | Positive regulation of sodium:hydrogen antiporter activity | NAS | biological_process |
| GO:0042803 | Protein homodimerization activity | TAS | molecular_function |
| GO:0042981 | Regulation of apoptotic process | NAS | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0047485 | Protein N-terminus binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0048549 | Positive regulation of pinocytosis | IEA | biological_process |
| GO:0051015 | Actin filament binding | IDA | molecular_function |
| GO:0051017 | Actin filament bundle assembly | IEA | biological_process |
| GO:0051271 | Negative regulation of cellular component movement | IEA | biological_process |
| GO:0051272 | Positive regulation of cellular component movement | IDA IMP | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0070830 | Tight junction assembly | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7705462938 | 0.0390646860 | 0.9999902473 | 0.3728142132 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0122311447 |
| GSE13712_SHEAR | Down | -0.1673634382 |
| GSE13712_STATIC | Down | -0.0973873563 |
| GSE19018 | Up | 0.4139407966 |
| GSE19899_A1 | Down | -1.2326297838 |
| GSE19899_A2 | Down | -0.2911366879 |
| PubMed_21979375_A1 | Down | -0.0300987104 |
| PubMed_21979375_A2 | Up | 0.2374821165 |
| GSE35957 | Up | 0.0127945572 |
| GSE36640 | Up | 0.0197131892 |
| GSE54402 | Down | -0.0208191150 |
| GSE9593 | Down | -0.2892424617 |
| GSE43922 | Down | -0.2428602760 |
| GSE24585 | Up | 0.1508984272 |
| GSE37065 | Down | -0.1195661961 |
| GSE28863_A1 | Down | -0.0903624286 |
| GSE28863_A2 | Down | -0.1555962203 |
| GSE28863_A3 | Down | -0.1299381587 |
| GSE28863_A4 | Up | 0.0110670214 |
| GSE48662 | Down | -0.0089421030 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023681 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-935 | MIMAT0004978 | MIRT036683 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037676 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038369 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039177 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039568 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040028 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040634 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041470 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042783 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT043003 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043214 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-5p | MIMAT0000731 | MIRT043999 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044609 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045364 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046259 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT047208 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT048735 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050151 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050392 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051105 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051747 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051940 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
