HCSGD entry for CDK2AP1
1. General information
| Official gene symbol | CDK2AP1 |
|---|---|
| Entrez ID | 8099 |
| Gene full name | cyclin-dependent kinase 2 associated protein 1 |
| Other gene symbols | DOC1 DORC1 ST19 doc-1 p12DOC-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000084 | Mitotic S phase | TAS | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9763396945 | 0.2317253562 | 0.9999902473 | 0.9272184707 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0899460120 |
| GSE13712_SHEAR | Down | -0.2443040163 |
| GSE13712_STATIC | Down | -0.1280389515 |
| GSE19018 | Up | 0.0614409201 |
| GSE19899_A1 | Down | -0.1436449975 |
| GSE19899_A2 | Down | -0.0055428981 |
| PubMed_21979375_A1 | Down | -0.2456197399 |
| PubMed_21979375_A2 | Down | -0.1854573785 |
| GSE35957 | Down | -0.0094242247 |
| GSE36640 | Down | -0.0245524248 |
| GSE54402 | Down | -0.0372660168 |
| GSE9593 | Up | 0.1246732007 |
| GSE43922 | Down | -0.1044073814 |
| GSE24585 | Down | -0.1230753934 |
| GSE37065 | Down | -0.0621629911 |
| GSE28863_A1 | Down | -0.1291460646 |
| GSE28863_A2 | Down | -0.0240424272 |
| GSE28863_A3 | Up | 0.1068762791 |
| GSE28863_A4 | Up | 0.0127156408 |
| GSE48662 | Down | -0.2369415823 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT005974 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21191961 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT005974 | Reporter assay | Functional MTI | 21328460 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040895 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12097237 | In addition, new pathways and cell cycle regulatory proteins, such as p12(DOC-1), are being discovered |
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