HCSGD entry for YEATS4

1. General information

Official gene symbolYEATS4
Entrez ID8089
Gene full nameYEATS domain containing 4
Other gene symbols4930573H17Rik B230215M10Rik GAS41 NUBI-1 YAF9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0005200Structural constituent of cytoskeletonNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmIDA IEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0007067MitosisNASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0016363Nuclear matrixNAScellular_component
GO:0035267NuA4 histone acetyltransferase complexIDAcellular_component
GO:0040008Regulation of growthIEAbiological_process
GO:0043967Histone H4 acetylationIDAbiological_process
GO:0043968Histone H2A acetylationIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84921105200.02503798110.99999024730.3048180222

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4514971522
GSE13712_SHEARUp0.1978445809
GSE13712_STATICUp0.1333778881
GSE19018Down-0.2092255634
GSE19899_A1Down-0.4335214710
GSE19899_A2Down-0.3149625856
PubMed_21979375_A1Up0.2862082911
PubMed_21979375_A2Down-0.1168160369
GSE35957Down-1.3339606422
GSE36640Down-1.9378325421
GSE54402Down-0.0688071087
GSE9593Down-0.1237769030
GSE43922Up0.0544991999
GSE24585Up0.0878789824
GSE37065Down-0.2478998276
GSE28863_A1Down-0.2522034299
GSE28863_A2Up0.3398995678
GSE28863_A3Down-0.1345850611
GSE28863_A4Up0.1786662187
GSE48662Down-0.5135573349

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24170126YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway
24170126We conducted an integrative analysis of gene expression and copy number in 261 non-small cell lung cancers (NSCLC) relative to matched normal tissues to define novel candidate oncogenes, identifying 12q13-15 and more specifically the YEATS4 gene as amplified and overexpressed in ~20% of the NSCLC cases examined
24170126Overexpression of YEATS4 abrogated senescence in human bronchial epithelial cells
24170126Conversely, RNAi-mediated attenuation of YEATS4 in human lung cancer cells reduced their proliferation and tumor growth, impairing colony formation and inducing cellular senescence
24170126We also found that YEATS4 expression affected cellular responses to cisplastin, with increased levels associated with resistance and decreased levels with sensitivity
24170126Taken together, our findings reveal YEATS4 as a candidate oncogene amplified in NSCLC, and a novel mechanism contributing to NSCLC pathogenesis
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