HCSGD entry for DUSP16
1. General information
| Official gene symbol | DUSP16 |
|---|---|
| Entrez ID | 80824 |
| Gene full name | dual specificity phosphatase 16 |
| Other gene symbols | MKP-7 MKP7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000188 | Inactivation of MAPK activity | IBA IEA TAS | biological_process |
| GO:0004721 | Phosphoprotein phosphatase activity | TAS | molecular_function |
| GO:0004725 | Protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IBA IEA TAS | cellular_component |
| GO:0005737 | Cytoplasm | IBA IEA TAS | cellular_component |
| GO:0006470 | Protein dephosphorylation | IBA | biological_process |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0016311 | Dephosphorylation | TAS | biological_process |
| GO:0016791 | Phosphatase activity | IEA | molecular_function |
| GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity | IBA | molecular_function |
| GO:0045204 | MAPK export from nucleus | TAS | biological_process |
| GO:0045209 | MAPK phosphatase export from nucleus, leptomycin B sensitive | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0046744539 | 0.9804600509 | 0.1798776316 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0004061370 |
| GSE13712_SHEAR | Up | 0.8293661609 |
| GSE13712_STATIC | Up | 0.5142293623 |
| GSE19018 | Down | -0.0197426412 |
| GSE19899_A1 | Up | 0.0977450138 |
| GSE19899_A2 | Up | 1.2372899959 |
| PubMed_21979375_A1 | Up | 1.3699679220 |
| PubMed_21979375_A2 | Up | 1.1100932965 |
| GSE35957 | Down | -0.2504952953 |
| GSE36640 | Down | -0.2069367954 |
| GSE54402 | Up | 0.7119124276 |
| GSE9593 | Down | -0.0690906086 |
| GSE43922 | Up | 0.8019960950 |
| GSE24585 | Up | 0.2238923791 |
| GSE37065 | Up | 0.3473954640 |
| GSE28863_A1 | Up | 1.1721233801 |
| GSE28863_A2 | Up | 0.4197631916 |
| GSE28863_A3 | Down | -0.0344544552 |
| GSE28863_A4 | Up | 0.0248031310 |
| GSE48662 | Down | -0.0977442625 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016920 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026190 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26381291 | DUSP16 ablation arrests the cell cycle and induces cellular senescence |
| 26381291 | In particular, we showed that DUSP16 ablation leads to a G1/S transition arrest, reduced incorporation of 5-bromodeoxyuridine, enhanced senescence-associated beta-galactosidase activity, and formation of senescence-associated heterochromatic foci |
| 26381291 | Mechanistically, DUSP16 silencing causes cellular senescence by activating the tumor suppressors p53 and Rb |
| 26381291 | The phosphatase activity of DUSP16 is necessary for antagonizing cellular senescence |
| 26381291 | Importantly, the expression levels of DUSP16 are up-regulated in human liver cancers, and are positively correlated with tumor cell proliferation |
| 26381291 | Taken together, our findings indicate that DUSP16 plays a role in tumorigenesis by protecting cancer cells from senescence |
| 25077541 | We demonstrate that miR-17 targets both ADCY5 and IRS1, upregulating the downstream signals MKP7, FoxO3, LC3B, and HIF1alpha, and downregulating mTOR, c-myc, cyclin D1, and JNK |
| 25077541 | Repression of ADCY5 by miR-17 translocated membrane-bound RGS2 into the nucleus, promoting interactions of RGS2 with HIF1alpha and the MKP7 promoter, enhancing MKP7 transcription |
| 25077541 | ADCY5 repression by miR-17 also facilitated the translocation of EGFR and MKP7 from membrane into cytoplasmic and mitochondrial fractions |
| 25077541 | Importantly, we found that MKP7 inhibited senescence by dephosphorylating PRAS40 at Thr246 and mTOR at Ser2248, facilitating the interaction and loss of function of both molecules |
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